FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2425754172> ?p ?o ?g. }

• W2425754172 endingPage "8" @default.
• W2425754172 startingPage "1" @default.
• W2425754172 abstract "The inflammatory response after polymer-based drug-eluting stent (DES) placement has recently emerged as a major concern. The biologic roles of peroxisome proliferator-activated receptor-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>γ</mml:mi></mml:mrow></mml:math>(PPAR-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mi>γ</mml:mi></mml:mrow></mml:math>) activators thiazolidinedione (TZD) remain controversial in cardiovascular disease. Herein, we investigated the antiinflammatory effects of pioglitazone (PIO) on circulating peripheral blood mononuclear cells (MNCs) in patients after coronary DES implantation. Methods and Results . Twenty-eight patients with coronary artery disease and who underwent DES implantations were randomly assigned to pioglitazone (30 mg/d; PIO) or placebo (control; Con) treatment in addition to optimal standard therapy. After 12 weeks of treatment, plasma concentrations of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:mi>α</mml:mi></mml:mrow></mml:math>(TNF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:mi>α</mml:mi></mml:mrow></mml:math>), and matrix metalloproteinase-9 (MMP-9) were significantly decreased in PIO group compared to the Con group (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.035</mml:mn></mml:math>, 0.011, 0.008, and 0.012, resp.). DES-induced mRNA expressions of IL-6, TNF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mrow><mml:mi>α</mml:mi></mml:mrow></mml:math>, and MMP-9 in circulating MNC were significantly blocked by PIO (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.031</mml:mn></mml:math>, 0.012, and 0.007, resp.). In addition, PIO markedly inhibited DES-enhanced NF- κ B function and DES-blocked PPAR-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mrow><mml:mi>γ</mml:mi></mml:mrow></mml:math>activity. Mechanically, DES induced PPAR-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mrow><mml:mi>γ</mml:mi></mml:mrow></mml:math>ubiquitination and degradation in protein level, which can be totally reversed by PIO. Conclusion . PIO treatment attenuated DES-induced PPAR loss, NF- κ B activation, and proinflammation, indicating that PIO may have a novel direct protective role in modulating proinflammation in DES era." @default.
• W2425754172 created "2016-06-24" @default.
• W2425754172 creator A5014014218 @default.
• W2425754172 creator A5019922407 @default.
• W2425754172 creator A5021925733 @default.
• W2425754172 creator A5024818901 @default.
• W2425754172 creator A5027317538 @default.
• W2425754172 creator A5035701638 @default.
• W2425754172 creator A5038615864 @default.
• W2425754172 creator A5080293953 @default.
• W2425754172 creator A5091185552 @default.
• W2425754172 date "2016-01-01" @default.
• W2425754172 modified "2023-10-17" @default.
• W2425754172 title "Pioglitazone Attenuates Drug-Eluting Stent-Induced Proinflammatory State in Patients by Blocking Ubiquitination of PPAR" @default.
• W2425754172 cites W1511195742 @default.
• W2425754172 cites W1841635074 @default.
• W2425754172 cites W1968243232 @default.
• W2425754172 cites W1968528328 @default.
• W2425754172 cites W1990724339 @default.
• W2425754172 cites W1997608954 @default.
• W2425754172 cites W2021758696 @default.
• W2425754172 cites W2035341808 @default.
• W2425754172 cites W2057218988 @default.
• W2425754172 cites W2081888412 @default.
• W2425754172 cites W2086040049 @default.
• W2425754172 cites W2086408606 @default.
• W2425754172 cites W2087058182 @default.
• W2425754172 cites W2104135200 @default.
• W2425754172 cites W2108723947 @default.
• W2425754172 cites W2119470649 @default.
• W2425754172 cites W2127125241 @default.
• W2425754172 cites W2135028356 @default.
• W2425754172 cites W2141178137 @default.
• W2425754172 cites W2148160920 @default.
• W2425754172 cites W2159969745 @default.
• W2425754172 cites W2168332555 @default.
• W2425754172 cites W2419162348 @default.
• W2425754172 doi "https://doi.org/10.1155/2016/7407153" @default.
• W2425754172 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4923578" @default.
• W2425754172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27403152" @default.
• W2425754172 hasPublicationYear "2016" @default.
• W2425754172 type Work @default.
• W2425754172 sameAs 2425754172 @default.
• W2425754172 citedByCount "5" @default.
• W2425754172 countsByYear W24257541722017 @default.
• W2425754172 countsByYear W24257541722018 @default.
• W2425754172 countsByYear W24257541722019 @default.
• W2425754172 countsByYear W24257541722020 @default.
• W2425754172 countsByYear W24257541722023 @default.
• W2425754172 crossrefType "journal-article" @default.
• W2425754172 hasAuthorship W2425754172A5014014218 @default.
• W2425754172 hasAuthorship W2425754172A5019922407 @default.
• W2425754172 hasAuthorship W2425754172A5021925733 @default.
• W2425754172 hasAuthorship W2425754172A5024818901 @default.
• W2425754172 hasAuthorship W2425754172A5027317538 @default.
• W2425754172 hasAuthorship W2425754172A5035701638 @default.
• W2425754172 hasAuthorship W2425754172A5038615864 @default.
• W2425754172 hasAuthorship W2425754172A5080293953 @default.
• W2425754172 hasAuthorship W2425754172A5091185552 @default.
• W2425754172 hasBestOaLocation W24257541721 @default.
• W2425754172 hasConcept C11413529 @default.
• W2425754172 hasConcept C126322002 @default.
• W2425754172 hasConcept C134018914 @default.
• W2425754172 hasConcept C2777180221 @default.
• W2425754172 hasConcept C2778213512 @default.
• W2425754172 hasConcept C2778384471 @default.
• W2425754172 hasConcept C33923547 @default.
• W2425754172 hasConcept C555293320 @default.
• W2425754172 hasConcept C71924100 @default.
• W2425754172 hasConceptScore W2425754172C11413529 @default.
• W2425754172 hasConceptScore W2425754172C126322002 @default.
• W2425754172 hasConceptScore W2425754172C134018914 @default.
• W2425754172 hasConceptScore W2425754172C2777180221 @default.
• W2425754172 hasConceptScore W2425754172C2778213512 @default.
• W2425754172 hasConceptScore W2425754172C2778384471 @default.
• W2425754172 hasConceptScore W2425754172C33923547 @default.
• W2425754172 hasConceptScore W2425754172C555293320 @default.
• W2425754172 hasConceptScore W2425754172C71924100 @default.
• W2425754172 hasFunder F4320321001 @default.
• W2425754172 hasLocation W24257541721 @default.
• W2425754172 hasLocation W24257541722 @default.
• W2425754172 hasLocation W24257541723 @default.
• W2425754172 hasLocation W24257541724 @default.
• W2425754172 hasOpenAccess W2425754172 @default.
• W2425754172 hasPrimaryLocation W24257541721 @default.
• W2425754172 hasRelatedWork W1986410768 @default.
• W2425754172 hasRelatedWork W2033522292 @default.
• W2425754172 hasRelatedWork W2042938358 @default.
• W2425754172 hasRelatedWork W2046264850 @default.
• W2425754172 hasRelatedWork W2115946307 @default.
• W2425754172 hasRelatedWork W2121496639 @default.
• W2425754172 hasRelatedWork W2163547766 @default.
• W2425754172 hasRelatedWork W2412747875 @default.
• W2425754172 hasRelatedWork W2981672174 @default.
• W2425754172 hasRelatedWork W8919293 @default.
• W2425754172 hasVolume "2016" @default.
• W2425754172 isParatext "false" @default.
• W2425754172 isRetracted "false" @default.

• next