Matches in SemOpenAlex for { <https://semopenalex.org/work/W2425777295> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2425777295 endingPage "33" @default.
- W2425777295 startingPage "21" @default.
- W2425777295 abstract "Toxic effects of gallium arsenide (GaAs), indium arsenide (InAs) and arsenic trioxide (As2O3) were studied in male Syrian golden hamsters. GaAs (7.7 mg/kg) and As2O3 (1.3 mg/kg) particles were instilled intratracheally twice a week a total of 16 times, while InAs (7.7 mg/kg) was instilled a total of 14 times. As a control, hamsters were treated with the vehicle, phosphate buffer solution. During the instillation period, the cumulative body weight gain of the InAs-, but not the GaAs- or As2O3-treated hamsters was suppressed significantly, when compared with the control group. Slight to severe inflammatory responses were observed in the lung for all treatment groups. The most severe inflammatory change, characterized by an accumulation of neutrophils and macrophages, exudation, thickness of the pleura and fibrotic proliferation was found in the InAs-treated hamsters. Extensive alveolar or bronchiolar cell hyperplasia with or without keratinizing squamous cell metaplasia was observed in almost all the InAs-treated hamsters. Furthermore, squamous cell metaplasia or squamous cell hyperplasia developed in some of the InAs-treated hamsters, but not in the GaAs- or As2O3-treated hamsters. Slight to mild lesions were found in the convoluted tubules of the kidney in both the GaAs and InAs groups. From the present study, the toxic potency of these particles was provisionally estimated to be in the following order: InAs > GaAs > As2O3, at the dosage level used in this study. Furthermore, there was evidence that InAs particles could induce pulmonary, renal or systemic toxicity, and as such, InAs particles may produce pulmonary precancerous change when instilled intratracheally into hamsters." @default.
- W2425777295 created "2016-06-24" @default.
- W2425777295 creator A5009084626 @default.
- W2425777295 creator A5013900477 @default.
- W2425777295 creator A5015565394 @default.
- W2425777295 creator A5036355904 @default.
- W2425777295 creator A5046274460 @default.
- W2425777295 creator A5051959379 @default.
- W2425777295 creator A5071551273 @default.
- W2425777295 creator A5072178889 @default.
- W2425777295 date "2000-01-01" @default.
- W2425777295 modified "2023-09-25" @default.
- W2425777295 title "Comparative study of the toxic effects of gallium arsenide, indium arsenide and arsenic trioxide following intratracheal instillations to the lung of Syrian golden hamsters." @default.
- W2425777295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10714013" @default.
- W2425777295 hasPublicationYear "2000" @default.
- W2425777295 type Work @default.
- W2425777295 sameAs 2425777295 @default.
- W2425777295 citedByCount "7" @default.
- W2425777295 countsByYear W24257772952013 @default.
- W2425777295 countsByYear W24257772952017 @default.
- W2425777295 countsByYear W24257772952018 @default.
- W2425777295 countsByYear W24257772952019 @default.
- W2425777295 crossrefType "journal-article" @default.
- W2425777295 hasAuthorship W2425777295A5009084626 @default.
- W2425777295 hasAuthorship W2425777295A5013900477 @default.
- W2425777295 hasAuthorship W2425777295A5015565394 @default.
- W2425777295 hasAuthorship W2425777295A5036355904 @default.
- W2425777295 hasAuthorship W2425777295A5046274460 @default.
- W2425777295 hasAuthorship W2425777295A5051959379 @default.
- W2425777295 hasAuthorship W2425777295A5071551273 @default.
- W2425777295 hasAuthorship W2425777295A5072178889 @default.
- W2425777295 hasConcept C126322002 @default.
- W2425777295 hasConcept C134018914 @default.
- W2425777295 hasConcept C142724271 @default.
- W2425777295 hasConcept C1491633281 @default.
- W2425777295 hasConcept C185592680 @default.
- W2425777295 hasConcept C190283241 @default.
- W2425777295 hasConcept C192562407 @default.
- W2425777295 hasConcept C2777562237 @default.
- W2425777295 hasConcept C2777714996 @default.
- W2425777295 hasConcept C2778575167 @default.
- W2425777295 hasConcept C2778981785 @default.
- W2425777295 hasConcept C2779357193 @default.
- W2425777295 hasConcept C2779525107 @default.
- W2425777295 hasConcept C2780386689 @default.
- W2425777295 hasConcept C49040817 @default.
- W2425777295 hasConcept C510052550 @default.
- W2425777295 hasConcept C529295009 @default.
- W2425777295 hasConcept C55493867 @default.
- W2425777295 hasConcept C71924100 @default.
- W2425777295 hasConceptScore W2425777295C126322002 @default.
- W2425777295 hasConceptScore W2425777295C134018914 @default.
- W2425777295 hasConceptScore W2425777295C142724271 @default.
- W2425777295 hasConceptScore W2425777295C1491633281 @default.
- W2425777295 hasConceptScore W2425777295C185592680 @default.
- W2425777295 hasConceptScore W2425777295C190283241 @default.
- W2425777295 hasConceptScore W2425777295C192562407 @default.
- W2425777295 hasConceptScore W2425777295C2777562237 @default.
- W2425777295 hasConceptScore W2425777295C2777714996 @default.
- W2425777295 hasConceptScore W2425777295C2778575167 @default.
- W2425777295 hasConceptScore W2425777295C2778981785 @default.
- W2425777295 hasConceptScore W2425777295C2779357193 @default.
- W2425777295 hasConceptScore W2425777295C2779525107 @default.
- W2425777295 hasConceptScore W2425777295C2780386689 @default.
- W2425777295 hasConceptScore W2425777295C49040817 @default.
- W2425777295 hasConceptScore W2425777295C510052550 @default.
- W2425777295 hasConceptScore W2425777295C529295009 @default.
- W2425777295 hasConceptScore W2425777295C55493867 @default.
- W2425777295 hasConceptScore W2425777295C71924100 @default.
- W2425777295 hasIssue "1" @default.
- W2425777295 hasLocation W24257772951 @default.
- W2425777295 hasOpenAccess W2425777295 @default.
- W2425777295 hasPrimaryLocation W24257772951 @default.
- W2425777295 hasRelatedWork W127964721 @default.
- W2425777295 hasRelatedWork W1964751987 @default.
- W2425777295 hasRelatedWork W1971524565 @default.
- W2425777295 hasRelatedWork W1983197863 @default.
- W2425777295 hasRelatedWork W2011481667 @default.
- W2425777295 hasRelatedWork W2016096247 @default.
- W2425777295 hasRelatedWork W2026082126 @default.
- W2425777295 hasRelatedWork W2132441318 @default.
- W2425777295 hasRelatedWork W2425777295 @default.
- W2425777295 hasRelatedWork W4290384649 @default.
- W2425777295 hasVolume "91" @default.
- W2425777295 isParatext "false" @default.
- W2425777295 isRetracted "false" @default.
- W2425777295 magId "2425777295" @default.
- W2425777295 workType "article" @default.