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• W2425966449 abstract "alphaNAC is a transcriptional coactivator known to interact with the N-terminal activation domain of the c-Jun transcription factor. In this article, we describe the identification of the c-Jun interaction domain within the alphaNAC protein. Deletion analysis of alphaNAC indicated that the c-Jun binding site was located in the middle part of the protein, between residues 89 and 129. The deletion of the C-terminal end of alphaNAC, including the c-Jun interacting domain, induced a nuclear translocation of the mutated coactivator. Despite its presence in the nucleus, this deletion mutant did not retain the capacity to coactivate an AP-1 response. These results demonstrate that the interaction between alphaNAC and c-Jun was necessary for the potentiation of theAP-1 transcriptional activity. These data are consistent with a mechanism by which alphaNAC acts as a coactivator for c-Jun-dependent transcription by interacting with the c-Jun N-terminal activation domain." @default.
• W2425966449 created "2016-06-24" @default.
• W2425966449 creator A5048933317 @default.
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• W2425966449 date "2002-05-01" @default.
• W2425966449 modified "2023-10-03" @default.
• W2425966449 title "αNAC Requires an Interaction With c-Jun to Exert its Transcriptional Coactivation" @default.
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• W2425966449 doi "https://doi.org/10.3727/000000002783992433" @default.
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