FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2426209056> ?p ?o ?g. }

• W2426209056 endingPage "e0157430" @default.
• W2426209056 startingPage "e0157430" @default.
• W2426209056 abstract "Sulforaphane (SFN) and moringin (GMG-ITC) are edible isothiocyanates present as glucosinolate precursors in cruciferous vegetables and in the plant Moringa oleifera respectively, and recognized for their chemopreventive and medicinal properties. In contrast to the well-studied SFN, little is known about the molecular pathways targeted by GMG-ITC. We investigated the ability of GMG-ITC to inhibit essential signaling pathways that are frequently upregulated in cancer and immune disorders, such as JAK/STAT and NF-κB. We report for the first time that, similarly to SFN, GMG-ITC in the nanomolar range suppresses IL-3-induced expression of STAT5 target genes. GMG-ITC, like SFN, does not inhibit STAT5 phosphorylation, suggesting a downstream inhibitory event. Interestingly, treatment with GMG-ITC or SFN had a limited inhibitory effect on IFNα-induced STAT1 and STAT2 activity, indicating that both isothiocyanates differentially target JAK/STAT signaling pathways. Furthermore, we showed that GMG-ITC in the micromolar range is a more potent inhibitor of TNF-induced NF-κB activity than SFN. Finally, using a cellular system mimicking constitutive active STAT5-induced cell transformation, we demonstrated that SFN can reverse the survival and growth advantage mediated by oncogenic STAT5 and triggers cell death, therefore providing experimental evidence of a cancer chemopreventive activity of SFN. This work thus identified STAT5, and to a lesser extent STAT1/STAT2, as novel targets of moringin. It also contributes to a better understanding of the biological activities of the dietary isothiocyanates GMG-ITC and SFN and further supports their apparent beneficial role in the prevention of chronic illnesses such as cancer, inflammatory diseases and immune disorders." @default.
• W2426209056 created "2016-06-24" @default.
• W2426209056 creator A5013043919 @default.
• W2426209056 creator A5019077858 @default.
• W2426209056 creator A5020155118 @default.
• W2426209056 creator A5038070269 @default.
• W2426209056 creator A5068254333 @default.
• W2426209056 creator A5069475148 @default.
• W2426209056 creator A5074173959 @default.
• W2426209056 creator A5082264190 @default.
• W2426209056 date "2016-06-15" @default.
• W2426209056 modified "2023-10-12" @default.
• W2426209056 title "The Chemopreventive Phytochemical Moringin Isolated from Moringa oleifera Seeds Inhibits JAK/STAT Signaling" @default.
• W2426209056 cites W1480729244 @default.
• W2426209056 cites W1491181689 @default.
• W2426209056 cites W1511429842 @default.
• W2426209056 cites W1560817952 @default.
• W2426209056 cites W1562263022 @default.
• W2426209056 cites W1608623592 @default.
• W2426209056 cites W1671779243 @default.
• W2426209056 cites W1874333181 @default.
• W2426209056 cites W1914674710 @default.
• W2426209056 cites W1917578864 @default.
• W2426209056 cites W1964614068 @default.
• W2426209056 cites W1967077010 @default.
• W2426209056 cites W1969176330 @default.
• W2426209056 cites W1969237028 @default.
• W2426209056 cites W1972283659 @default.
• W2426209056 cites W1980155183 @default.
• W2426209056 cites W1981155770 @default.
• W2426209056 cites W1989957102 @default.
• W2426209056 cites W1991201692 @default.
• W2426209056 cites W1994267052 @default.
• W2426209056 cites W1994944002 @default.
• W2426209056 cites W1996740511 @default.
• W2426209056 cites W1997362033 @default.
• W2426209056 cites W1997965188 @default.
• W2426209056 cites W1999367215 @default.
• W2426209056 cites W2001761736 @default.
• W2426209056 cites W2001851523 @default.
• W2426209056 cites W2004068229 @default.
• W2426209056 cites W2008409819 @default.
• W2426209056 cites W2009278160 @default.
• W2426209056 cites W2019033423 @default.
• W2426209056 cites W2021270662 @default.
• W2426209056 cites W2024282024 @default.
• W2426209056 cites W2027697700 @default.
• W2426209056 cites W2033753214 @default.
• W2426209056 cites W2036153681 @default.
• W2426209056 cites W2041341438 @default.
• W2426209056 cites W2049578720 @default.
• W2426209056 cites W2051577500 @default.
• W2426209056 cites W2051726523 @default.
• W2426209056 cites W2052400079 @default.
• W2426209056 cites W2054931962 @default.
• W2426209056 cites W2062898287 @default.
• W2426209056 cites W2063637433 @default.
• W2426209056 cites W2065238506 @default.
• W2426209056 cites W2068538879 @default.
• W2426209056 cites W2076752985 @default.
• W2426209056 cites W2078844752 @default.
• W2426209056 cites W2080616919 @default.
• W2426209056 cites W2082745597 @default.
• W2426209056 cites W2082832752 @default.
• W2426209056 cites W2084409051 @default.
• W2426209056 cites W2099037325 @default.
• W2426209056 cites W2103565638 @default.
• W2426209056 cites W2105550924 @default.
• W2426209056 cites W2106946122 @default.
• W2426209056 cites W2107077050 @default.
• W2426209056 cites W2109770185 @default.
• W2426209056 cites W2110378711 @default.
• W2426209056 cites W2112716376 @default.
• W2426209056 cites W2115186999 @default.
• W2426209056 cites W2119128067 @default.
• W2426209056 cites W2119456915 @default.
• W2426209056 cites W2122953762 @default.
• W2426209056 cites W2123684526 @default.
• W2426209056 cites W2124674978 @default.
• W2426209056 cites W2128124948 @default.
• W2426209056 cites W2130148894 @default.
• W2426209056 cites W2132173287 @default.
• W2426209056 cites W2134540087 @default.
• W2426209056 cites W2143052000 @default.
• W2426209056 cites W2146913811 @default.
• W2426209056 cites W2150202119 @default.
• W2426209056 cites W2151465682 @default.
• W2426209056 cites W2153879016 @default.
• W2426209056 cites W2154062229 @default.
• W2426209056 cites W2157930170 @default.
• W2426209056 cites W2159483584 @default.
• W2426209056 cites W2160009495 @default.
• W2426209056 cites W2160946368 @default.
• W2426209056 cites W2162384201 @default.
• W2426209056 cites W2171515981 @default.
• W2426209056 cites W2224782492 @default.
• W2426209056 cites W2261741354 @default.
• W2426209056 cites W2312699611 @default.

• next