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• W2426331352 abstract "In murine collagen-induced arthritis (CIA), self-reactive T cells can recognize peptide antigens derived from type-II collagen (CII). Activation of T cells is an important mediator of autoimmune diseases. Thus, T cells have become a focal point of study to treat autoimmune diseases. In this study, we evaluated the efficacy of recombinant MHC class II molecules in the regulation of antigen-specific T cells by using a self peptide derived from CII (CII260-274; IAGFKGEQGPKGEPG) linked to mouse I-A(q) in a murine CIA model. We found that recombinant I-A(q)/CII260-274 molecules could be recognized by CII-specific T cells and inhibit the same T cells in vitro. Furthermore, the development of CIA in mice was successfully prevented by in vivo injection of recombinant I-A(q)/CII260-274 molecules. Thus, treatment with recombinant soluble MHC class II molecules in complex with an immunodominant self-peptide might offer a potential therapeutic for chronic inflammation in autoimmune disease such as rheumatoid arthritis. [BMB Reports 2016; 49(6): 331-336]." @default.
• W2426331352 created "2016-06-24" @default.
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• W2426331352 date "2016-06-30" @default.
• W2426331352 modified "2023-09-26" @default.
• W2426331352 title "Induction of tolerance against the arthritogenic antigen with type-II collagen peptide-linked soluble MHC class II molecules" @default.
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• W2426331352 doi "https://doi.org/10.5483/bmbrep.2016.49.6.207" @default.
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