Matches in SemOpenAlex for { <https://semopenalex.org/work/W2426552466> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2426552466 endingPage "10" @default.
- W2426552466 startingPage "705" @default.
- W2426552466 abstract "Genetic factors have a definitive role in the etiology of ulcerative colitis (UC). The mode of inheritance suggests a polygenic disease with the penetrance of the genetic factors being strongly influenced by environmental factors. Several studies have been reported associations between UC and the polymorphism of genes that are located in the major histocompatibility complex (MHC) on the short arm of chromosome 6. The human leukocyte antigen (HLA) class II genes are candidates for a role in the pathogenesis of UC, because their products play a central role in the immune response. The MHC region contains numerous immune related genes, and it has now become clear that different alleles of the MHC genes are strongly linked. Association studies have suggested a role for HLA-DR alleles in disease susceptibility to UC. Thus, HLA-DRB1*0103, DRB1*1502 and DRB1*12 were found to be positively associated with UC. On the other hand, the tumor necrosis factor alpha (TNF-alpha) gene encodes a proinflammatory cytokine that is found in increased concentrations in the mucosa of patients with inflammatory bowel disease. The regulation of TNF expression is in part genetically determined because the polymorphisms -238, -308, -863, -857, and -1031 found in the promoter region are associated with increased TNF production. Recent data suggests that TNF polymorphism may be more important in determining susceptibility to UC and these TNF markers could predict response to infusion with chimeric anti-TNF antibody." @default.
- W2426552466 created "2016-06-24" @default.
- W2426552466 creator A5004969379 @default.
- W2426552466 date "2004-03-12" @default.
- W2426552466 modified "2023-09-23" @default.
- W2426552466 title "[Immunogenetics of chronic ulcerative colitis]." @default.
- W2426552466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15011740" @default.
- W2426552466 hasPublicationYear "2004" @default.
- W2426552466 type Work @default.
- W2426552466 sameAs 2426552466 @default.
- W2426552466 citedByCount "5" @default.
- W2426552466 countsByYear W24265524662013 @default.
- W2426552466 countsByYear W24265524662019 @default.
- W2426552466 crossrefType "journal-article" @default.
- W2426552466 hasAuthorship W2426552466A5004969379 @default.
- W2426552466 hasConcept C104317684 @default.
- W2426552466 hasConcept C127716648 @default.
- W2426552466 hasConcept C142724271 @default.
- W2426552466 hasConcept C147483822 @default.
- W2426552466 hasConcept C1547928 @default.
- W2426552466 hasConcept C164027704 @default.
- W2426552466 hasConcept C17991360 @default.
- W2426552466 hasConcept C180754005 @default.
- W2426552466 hasConcept C188280979 @default.
- W2426552466 hasConcept C200544954 @default.
- W2426552466 hasConcept C203014093 @default.
- W2426552466 hasConcept C207936829 @default.
- W2426552466 hasConcept C2776914184 @default.
- W2426552466 hasConcept C2778260677 @default.
- W2426552466 hasConcept C2779134260 @default.
- W2426552466 hasConcept C2780479503 @default.
- W2426552466 hasConcept C54355233 @default.
- W2426552466 hasConcept C71924100 @default.
- W2426552466 hasConcept C86803240 @default.
- W2426552466 hasConcept C8891405 @default.
- W2426552466 hasConceptScore W2426552466C104317684 @default.
- W2426552466 hasConceptScore W2426552466C127716648 @default.
- W2426552466 hasConceptScore W2426552466C142724271 @default.
- W2426552466 hasConceptScore W2426552466C147483822 @default.
- W2426552466 hasConceptScore W2426552466C1547928 @default.
- W2426552466 hasConceptScore W2426552466C164027704 @default.
- W2426552466 hasConceptScore W2426552466C17991360 @default.
- W2426552466 hasConceptScore W2426552466C180754005 @default.
- W2426552466 hasConceptScore W2426552466C188280979 @default.
- W2426552466 hasConceptScore W2426552466C200544954 @default.
- W2426552466 hasConceptScore W2426552466C203014093 @default.
- W2426552466 hasConceptScore W2426552466C207936829 @default.
- W2426552466 hasConceptScore W2426552466C2776914184 @default.
- W2426552466 hasConceptScore W2426552466C2778260677 @default.
- W2426552466 hasConceptScore W2426552466C2779134260 @default.
- W2426552466 hasConceptScore W2426552466C2780479503 @default.
- W2426552466 hasConceptScore W2426552466C54355233 @default.
- W2426552466 hasConceptScore W2426552466C71924100 @default.
- W2426552466 hasConceptScore W2426552466C86803240 @default.
- W2426552466 hasConceptScore W2426552466C8891405 @default.
- W2426552466 hasIssue "6" @default.
- W2426552466 hasLocation W24265524661 @default.
- W2426552466 hasOpenAccess W2426552466 @default.
- W2426552466 hasPrimaryLocation W24265524661 @default.
- W2426552466 hasRelatedWork W1993739557 @default.
- W2426552466 hasRelatedWork W2008854574 @default.
- W2426552466 hasRelatedWork W2154347489 @default.
- W2426552466 hasRelatedWork W2164021954 @default.
- W2426552466 hasRelatedWork W2170115400 @default.
- W2426552466 hasRelatedWork W2372263582 @default.
- W2426552466 hasRelatedWork W2426552466 @default.
- W2426552466 hasRelatedWork W2474703626 @default.
- W2426552466 hasRelatedWork W2598386321 @default.
- W2426552466 hasRelatedWork W46123407 @default.
- W2426552466 hasVolume "55" @default.
- W2426552466 isParatext "false" @default.
- W2426552466 isRetracted "false" @default.
- W2426552466 magId "2426552466" @default.
- W2426552466 workType "article" @default.