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• W2426701344 abstract "In an effort to identify an HIV-1 capsid assembly inhibitor with improved solubility and potency, we synthesized two series of pyrimidine analogues based on our earlier lead compound N-(4-(ethoxycarbonyl)phenyl)-2-(pyridine-4-yl)quinazoline-4-amine. In vitro binding experiments showed that our series of 2-pyridine-4-ylpyrimidines had IC50 values higher than 28μM. Our series of 2-pyridine-3-ylpyrimidines exhibited IC50 values ranging from 3 to 60μM. The congeners with a fluoro substituent introduced at the 4-N-phenyl moiety, along with a methyl at C-6, represent potent HIV capsid assembly inhibitors binding to the C-terminal domain of the capsid protein." @default.
• W2426701344 created "2016-06-24" @default.
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• W2426701344 date "2016-08-01" @default.
• W2426701344 modified "2023-10-16" @default.
• W2426701344 title "Synthesis and evaluation of 2-pyridinylpyrimidines as inhibitors of HIV-1 structural protein assembly" @default.
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• W2426701344 doi "https://doi.org/10.1016/j.bmcl.2016.06.039" @default.
• W2426701344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27353536" @default.
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