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- W2426702951 abstract "Electrical stimulation of rat hypothalamic synaptosome suspensions produced activation of tyrosine hydroxylase due to increase of the affinity for tyrosine and 6,7-dimethyl-5,6,7,8-tetrahydropterine cofactor, decrease of the affinity for dopamine and enhancement of substrate inhibition. Cocaine (10(-7) - 10(-5) M) in vitro caused enzyme activation; when administered to animals systemically (0.5 mg/kg) the drug produced inhibition of hypothalamic tyrosine hydroxylase probably through a receptor-mediated feedback mechanism." @default.
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- W2426702951 date "1978-01-01" @default.
- W2426702951 modified "2023-09-23" @default.
- W2426702951 title "Brain tyrosine hydroxylase: kinetic properties and regulation of the activity." @default.
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