FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2426969880> ?p ?o ?g. }

• W2426969880 endingPage "81" @default.
• W2426969880 startingPage "75" @default.
• W2426969880 abstract "Cancer cells usually utilize glucose as a carbon source for aerobic glycolysis, which is named as ``Warburg effect''. Recent studies have shown that MicroRNAs (miRNAs), a class of short and non-coding RNAs, play a role in the regulation of metabolic reprograming in cancer cells. In the present stu dy, we report that miR-181b negatively regulates glycolysis in gastric cancer cells. Over-expression of miR-181b mimics reduces the glucose uptake and lactate production, while increasing the cellular ATP levels in NCI-N87 and MGC80-3 cells. At the molecular level, miR-181b directly inhibits the expression level of hexokinase 2 (HK2), a key enzyme that catalyzes the first step of glycolysis, through targeting its 3'-untranslated region. In addition, miR-181b represses cell proliferation and migration and is dramatically down-regulated in human gastric cancers. Therefore, our data disclose a novel function of miR-181b in reprogramming the metabolic process in gastric cancer." @default.
• W2426969880 created "2016-06-24" @default.
• W2426969880 creator A5006008485 @default.
• W2426969880 creator A5011090841 @default.
• W2426969880 creator A5021541475 @default.
• W2426969880 creator A5049692788 @default.
• W2426969880 creator A5052541437 @default.
• W2426969880 creator A5066828937 @default.
• W2426969880 date "2016-07-08" @default.
• W2426969880 modified "2023-10-17" @default.
• W2426969880 title "MicroRNA-181b inhibits glycolysis in gastric cancer cells via targeting hexokinase 2 gene" @default.
• W2426969880 cites W1979581732 @default.
• W2426969880 cites W1986630370 @default.
• W2426969880 cites W1987328298 @default.
• W2426969880 cites W1998166655 @default.
• W2426969880 cites W2000203225 @default.
• W2426969880 cites W2028897202 @default.
• W2426969880 cites W2037679360 @default.
• W2426969880 cites W2045962235 @default.
• W2426969880 cites W2055442199 @default.
• W2426969880 cites W2055671617 @default.
• W2426969880 cites W2056775743 @default.
• W2426969880 cites W2086965865 @default.
• W2426969880 cites W2092627144 @default.
• W2426969880 cites W2101117089 @default.
• W2426969880 cites W2105493915 @default.
• W2426969880 cites W2123890731 @default.
• W2426969880 cites W2128928017 @default.
• W2426969880 cites W2144323242 @default.
• W2426969880 cites W2156337600 @default.
• W2426969880 cites W2160588684 @default.
• W2426969880 cites W2165316668 @default.
• W2426969880 cites W2322015982 @default.
• W2426969880 cites W833792894 @default.
• W2426969880 doi "https://doi.org/10.3233/cbm-160619" @default.
• W2426969880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27314295" @default.
• W2426969880 hasPublicationYear "2016" @default.
• W2426969880 type Work @default.
• W2426969880 sameAs 2426969880 @default.
• W2426969880 citedByCount "38" @default.
• W2426969880 countsByYear W24269698802017 @default.
• W2426969880 countsByYear W24269698802018 @default.
• W2426969880 countsByYear W24269698802019 @default.
• W2426969880 countsByYear W24269698802020 @default.
• W2426969880 countsByYear W24269698802021 @default.
• W2426969880 countsByYear W24269698802022 @default.
• W2426969880 countsByYear W24269698802023 @default.
• W2426969880 crossrefType "journal-article" @default.
• W2426969880 hasAuthorship W2426969880A5006008485 @default.
• W2426969880 hasAuthorship W2426969880A5011090841 @default.
• W2426969880 hasAuthorship W2426969880A5021541475 @default.
• W2426969880 hasAuthorship W2426969880A5049692788 @default.
• W2426969880 hasAuthorship W2426969880A5052541437 @default.
• W2426969880 hasAuthorship W2426969880A5066828937 @default.
• W2426969880 hasConcept C104317684 @default.
• W2426969880 hasConcept C105580179 @default.
• W2426969880 hasConcept C109156525 @default.
• W2426969880 hasConcept C121608353 @default.
• W2426969880 hasConcept C145059251 @default.
• W2426969880 hasConcept C181199279 @default.
• W2426969880 hasConcept C185592680 @default.
• W2426969880 hasConcept C20251656 @default.
• W2426969880 hasConcept C2779826832 @default.
• W2426969880 hasConcept C502942594 @default.
• W2426969880 hasConcept C54355233 @default.
• W2426969880 hasConcept C55493867 @default.
• W2426969880 hasConcept C55885012 @default.
• W2426969880 hasConcept C77255625 @default.
• W2426969880 hasConcept C86803240 @default.
• W2426969880 hasConcept C89604277 @default.
• W2426969880 hasConcept C95444343 @default.
• W2426969880 hasConcept C96232424 @default.
• W2426969880 hasConceptScore W2426969880C104317684 @default.
• W2426969880 hasConceptScore W2426969880C105580179 @default.
• W2426969880 hasConceptScore W2426969880C109156525 @default.
• W2426969880 hasConceptScore W2426969880C121608353 @default.
• W2426969880 hasConceptScore W2426969880C145059251 @default.
• W2426969880 hasConceptScore W2426969880C181199279 @default.
• W2426969880 hasConceptScore W2426969880C185592680 @default.
• W2426969880 hasConceptScore W2426969880C20251656 @default.
• W2426969880 hasConceptScore W2426969880C2779826832 @default.
• W2426969880 hasConceptScore W2426969880C502942594 @default.
• W2426969880 hasConceptScore W2426969880C54355233 @default.
• W2426969880 hasConceptScore W2426969880C55493867 @default.
• W2426969880 hasConceptScore W2426969880C55885012 @default.
• W2426969880 hasConceptScore W2426969880C77255625 @default.
• W2426969880 hasConceptScore W2426969880C86803240 @default.
• W2426969880 hasConceptScore W2426969880C89604277 @default.
• W2426969880 hasConceptScore W2426969880C95444343 @default.
• W2426969880 hasConceptScore W2426969880C96232424 @default.
• W2426969880 hasIssue "1" @default.
• W2426969880 hasLocation W24269698801 @default.
• W2426969880 hasLocation W24269698802 @default.
• W2426969880 hasOpenAccess W2426969880 @default.
• W2426969880 hasPrimaryLocation W24269698801 @default.
• W2426969880 hasRelatedWork W2056444349 @default.
• W2426969880 hasRelatedWork W2137960344 @default.
• W2426969880 hasRelatedWork W2405190761 @default.

• next