Matches in SemOpenAlex for { <https://semopenalex.org/work/W2426974136> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2426974136 endingPage "42" @default.
- W2426974136 startingPage "3435" @default.
- W2426974136 abstract "TNF treatment causes oxidative down-modulation of endogenous survival factors in transformed as well as nontransformed fibroblasts. Endogenous survival factors are negative regulators of a constitutively expressed apoptosis machinery and have been defined in several cellular systems. As transformed cells harbour lower concentrations of endogenous survival factors than nontransformed parental cells, TNF-dependent down-modulation of endogenous survival factors in transformed cells is sufficient to release the apoptosis machinery from negative control and to cause cell death. In contrast, in nontransformed cells, due to their higher initial concentration of endogenous survival factors, down-modulation by TNF is not complete and therefore apoptosis is still prevented. Our data showed that perception of TNF signalling is not different between transformed and nontransformed cells, but that their differential response is due to quantitative differences in their regulatory setup. Furthermore, our data explained why application of low concentrations of cycloheximide can sensitize cells for apoptosis induction by TNF-alpha." @default.
- W2426974136 created "2016-06-24" @default.
- W2426974136 creator A5002097111 @default.
- W2426974136 creator A5004528618 @default.
- W2426974136 date "2000-12-29" @default.
- W2426974136 modified "2023-09-23" @default.
- W2426974136 title "Selective effect of tumor necrosis factor on transformed versus nontransformed cells: nonselective signal recognition but differential target cell response." @default.
- W2426974136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11131645" @default.
- W2426974136 hasPublicationYear "2000" @default.
- W2426974136 type Work @default.
- W2426974136 sameAs 2426974136 @default.
- W2426974136 citedByCount "3" @default.
- W2426974136 countsByYear W24269741362016 @default.
- W2426974136 crossrefType "journal-article" @default.
- W2426974136 hasAuthorship W2426974136A5002097111 @default.
- W2426974136 hasAuthorship W2426974136A5004528618 @default.
- W2426974136 hasConcept C134018914 @default.
- W2426974136 hasConcept C1491633281 @default.
- W2426974136 hasConcept C16613235 @default.
- W2426974136 hasConcept C17991360 @default.
- W2426974136 hasConcept C190283241 @default.
- W2426974136 hasConcept C203014093 @default.
- W2426974136 hasConcept C2778128677 @default.
- W2426974136 hasConcept C31573885 @default.
- W2426974136 hasConcept C502942594 @default.
- W2426974136 hasConcept C54355233 @default.
- W2426974136 hasConcept C55493867 @default.
- W2426974136 hasConcept C81885089 @default.
- W2426974136 hasConcept C86803240 @default.
- W2426974136 hasConcept C95444343 @default.
- W2426974136 hasConceptScore W2426974136C134018914 @default.
- W2426974136 hasConceptScore W2426974136C1491633281 @default.
- W2426974136 hasConceptScore W2426974136C16613235 @default.
- W2426974136 hasConceptScore W2426974136C17991360 @default.
- W2426974136 hasConceptScore W2426974136C190283241 @default.
- W2426974136 hasConceptScore W2426974136C203014093 @default.
- W2426974136 hasConceptScore W2426974136C2778128677 @default.
- W2426974136 hasConceptScore W2426974136C31573885 @default.
- W2426974136 hasConceptScore W2426974136C502942594 @default.
- W2426974136 hasConceptScore W2426974136C54355233 @default.
- W2426974136 hasConceptScore W2426974136C55493867 @default.
- W2426974136 hasConceptScore W2426974136C81885089 @default.
- W2426974136 hasConceptScore W2426974136C86803240 @default.
- W2426974136 hasConceptScore W2426974136C95444343 @default.
- W2426974136 hasIssue "5B" @default.
- W2426974136 hasLocation W24269741361 @default.
- W2426974136 hasOpenAccess W2426974136 @default.
- W2426974136 hasPrimaryLocation W24269741361 @default.
- W2426974136 hasRelatedWork W1565632507 @default.
- W2426974136 hasRelatedWork W2135339893 @default.
- W2426974136 hasRelatedWork W2145322052 @default.
- W2426974136 hasRelatedWork W2146549722 @default.
- W2426974136 hasRelatedWork W2368961166 @default.
- W2426974136 hasRelatedWork W2426974136 @default.
- W2426974136 hasRelatedWork W3158786004 @default.
- W2426974136 hasRelatedWork W3158909247 @default.
- W2426974136 hasRelatedWork W3160804663 @default.
- W2426974136 hasRelatedWork W2127396418 @default.
- W2426974136 hasVolume "20" @default.
- W2426974136 isParatext "false" @default.
- W2426974136 isRetracted "false" @default.
- W2426974136 magId "2426974136" @default.
- W2426974136 workType "article" @default.