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- W242707566 abstract "Castelman's disease (CD) or giant angiofollicular hyperplasia of lymphatic nodes is a rare disease caused by human herpes virus type 8 (HHV-8). This disease has a certain association with noncancer lymphoadenopathy. CD may be of solitary lesion or multicentric form (MCD). CD is accompanied by increasing level of interleukin-6 (IL-6) in blood. The course of CD may be complicated by the development of POEMS-syndrome. This study presents a case of two-year follow-up for patients with mixed variant of MCD, complicated by the development of POEMS-syndrome. MCD was proved by histological investigation of lymphatic node with histochemistry marking of CD21+ dendrite cells of follicle, increasing level of IL-6 and presence of HHV-8 in blood. The prevalence of lymphoadenopathy was estimated by computer tomography. POEMS-syndrome was diagnosed by the presence of all main diagnostic criteria: neuro-muscle conducting failure, high histochemistry activity of VEGF on all lymphatic node cells, connection of VEGF with capillary endothelium, presence of X-chain of immunoglobulin in blood, development of osteosclerosis and presence of own CD. In one's lifetime pituary gland micro adenoma has been revealed for the first time. Appearance of rare in POEMS-syndrome stable injury diffusion lung capacity with the development of lung hypertension and cor pulmonale has been proved. Patient received 6 courses of treatment by CHOP. Treatment had different influence on POEMS-syndrome and MCD features. It is stable remission of MCD during 2 years. POEMS features are more resistible for treatment" @default.
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- W242707566 date "2010-01-01" @default.
- W242707566 modified "2023-09-26" @default.
- W242707566 title "Болезнь Каслмана и POEMS-синдром" @default.
- W242707566 hasPublicationYear "2010" @default.
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