Matches in SemOpenAlex for { <https://semopenalex.org/work/W2427244273> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2427244273 endingPage "F473" @default.
- W2427244273 startingPage "F468" @default.
- W2427244273 abstract "By use of in vivo microperfusion methodology, we assessed proton secretion (acidification) in the superficial distal tubule of the rat by determining the rate of total CO2 (tCO2) absorption (JtCO2). In these studies, we compared the JtCO2 in rats fed a diet that increased urine pH to the JtCO2 in rats fed a high-protein diet that reduced urine pH. The effect of amiloride added to the perfusate, used in rats fed the high-protein diet, was also examined. In rats, Group 1, fed a commercial diet, urine pH was 6.9; plasma tCO2 was 30.0 mM, and JtCO2 was 15.5 +/- 5.3 pmol X mm-1 X min-1. Following the ingestion of a high-protein diet the night before study, the urine pH fell to 5.6 and the plasma tCO2 to 28.2 mM. The JtCO2 in this group, Group 2, 41.1 +/- 4.8 was significantly greater than Group 1, P less than 0.05. The late distal transepithelial potential difference was comparable in both groups, -50.3 +/- 4.3 vs. -45.2 +/- 3.1 mV, P not significant. In a third group, Group 3, amiloride (10(-4) M) was added to the perfusate of rats prepared as in Group 2. JtCO2 was 23.4 +/- 0.4 pmol X mm-1 X min-1, significantly less than Group 2, P less than 0.05. The transepithelial potential difference was reduced to -4.0 +/- 2.3 mV, P less than 0.01 vs. Group 2. We conclude that the superficial distal tubule of the rat responds to subtle stimuli to increase proton secretion and contributes to urinary acidification. The rate of acidification can be influenced by alterations in the electrical profile across the acidifying epithelium." @default.
- W2427244273 created "2016-06-24" @default.
- W2427244273 creator A5005232642 @default.
- W2427244273 creator A5032435920 @default.
- W2427244273 date "1987-03-01" @default.
- W2427244273 modified "2023-09-27" @default.
- W2427244273 title "Total CO2 absorption in the distal tubule of the rat" @default.
- W2427244273 doi "https://doi.org/10.1152/ajprenal.1987.252.3.f468" @default.
- W2427244273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3103468" @default.
- W2427244273 hasPublicationYear "1987" @default.
- W2427244273 type Work @default.
- W2427244273 sameAs 2427244273 @default.
- W2427244273 citedByCount "14" @default.
- W2427244273 countsByYear W24272442732014 @default.
- W2427244273 countsByYear W24272442732018 @default.
- W2427244273 crossrefType "journal-article" @default.
- W2427244273 hasAuthorship W2427244273A5005232642 @default.
- W2427244273 hasAuthorship W2427244273A5032435920 @default.
- W2427244273 hasConcept C10146269 @default.
- W2427244273 hasConcept C121332964 @default.
- W2427244273 hasConcept C125287762 @default.
- W2427244273 hasConcept C126322002 @default.
- W2427244273 hasConcept C134018914 @default.
- W2427244273 hasConcept C150903083 @default.
- W2427244273 hasConcept C178790620 @default.
- W2427244273 hasConcept C185592680 @default.
- W2427244273 hasConcept C193230392 @default.
- W2427244273 hasConcept C207001950 @default.
- W2427244273 hasConcept C24890656 @default.
- W2427244273 hasConcept C2779608910 @default.
- W2427244273 hasConcept C2780026642 @default.
- W2427244273 hasConcept C3018023364 @default.
- W2427244273 hasConcept C537181965 @default.
- W2427244273 hasConcept C55493867 @default.
- W2427244273 hasConcept C71924100 @default.
- W2427244273 hasConcept C86803240 @default.
- W2427244273 hasConceptScore W2427244273C10146269 @default.
- W2427244273 hasConceptScore W2427244273C121332964 @default.
- W2427244273 hasConceptScore W2427244273C125287762 @default.
- W2427244273 hasConceptScore W2427244273C126322002 @default.
- W2427244273 hasConceptScore W2427244273C134018914 @default.
- W2427244273 hasConceptScore W2427244273C150903083 @default.
- W2427244273 hasConceptScore W2427244273C178790620 @default.
- W2427244273 hasConceptScore W2427244273C185592680 @default.
- W2427244273 hasConceptScore W2427244273C193230392 @default.
- W2427244273 hasConceptScore W2427244273C207001950 @default.
- W2427244273 hasConceptScore W2427244273C24890656 @default.
- W2427244273 hasConceptScore W2427244273C2779608910 @default.
- W2427244273 hasConceptScore W2427244273C2780026642 @default.
- W2427244273 hasConceptScore W2427244273C3018023364 @default.
- W2427244273 hasConceptScore W2427244273C537181965 @default.
- W2427244273 hasConceptScore W2427244273C55493867 @default.
- W2427244273 hasConceptScore W2427244273C71924100 @default.
- W2427244273 hasConceptScore W2427244273C86803240 @default.
- W2427244273 hasIssue "3" @default.
- W2427244273 hasLocation W24272442731 @default.
- W2427244273 hasLocation W24272442732 @default.
- W2427244273 hasOpenAccess W2427244273 @default.
- W2427244273 hasPrimaryLocation W24272442731 @default.
- W2427244273 hasRelatedWork W2006202112 @default.
- W2427244273 hasRelatedWork W2020971262 @default.
- W2427244273 hasRelatedWork W2021846613 @default.
- W2427244273 hasRelatedWork W2059373368 @default.
- W2427244273 hasRelatedWork W2071789881 @default.
- W2427244273 hasRelatedWork W2074872267 @default.
- W2427244273 hasRelatedWork W2093166709 @default.
- W2427244273 hasRelatedWork W2094944521 @default.
- W2427244273 hasRelatedWork W2104218156 @default.
- W2427244273 hasRelatedWork W4240148004 @default.
- W2427244273 hasVolume "252" @default.
- W2427244273 isParatext "false" @default.
- W2427244273 isRetracted "false" @default.
- W2427244273 magId "2427244273" @default.
- W2427244273 workType "article" @default.