Matches in SemOpenAlex for { <https://semopenalex.org/work/W2427497595> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2427497595 endingPage "7" @default.
- W2427497595 startingPage "211" @default.
- W2427497595 abstract "A Columbian patient presented with a rare type of onychomycosis caused by Microsporum gypseum. Oral treatment with itraconazole formulation (Funazol) available in Columbia failed to improve the nail alteration. The fungitoxic effect of itraconazole was assessed on the M. gypseum strain cultured from the nail of the patient by using the method of culture of fungi on cyanoacrylate skin surface strippings (CSSS). In addition, a comparative evaluation of the oral bioavailability of itraconazole was made in volunteers after intake of Funazol and Sporanox. In the ex vivo bioassay on CSSS, topical itraconazole proved to be highly active against M. gypseum. After oral intake, however, the itraconazole bioavailability of Funazol relative to Sporanox averaged only 3.5%. Antifungal pulse therapy with Sporanox, 400 mg daily for 1 week per month for 4 months, cured the patient. This study shows that itraconazole is hardly or not absorbed from the oral formulation Funazol. Both the oral bioavailability and consequently therapeutic efficacy of the genuine drug (Sporanox) are highly superior." @default.
- W2427497595 created "2016-06-24" @default.
- W2427497595 creator A5001320577 @default.
- W2427497595 creator A5003476187 @default.
- W2427497595 creator A5012591748 @default.
- W2427497595 creator A5016292547 @default.
- W2427497595 creator A5020338238 @default.
- W2427497595 creator A5077517618 @default.
- W2427497595 date "1995-09-01" @default.
- W2427497595 modified "2023-09-27" @default.
- W2427497595 title "Paradoxical response to itraconazole treatment in a patient with onychomycosis caused by Microsporum gypseum." @default.
- W2427497595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8849298" @default.
- W2427497595 hasPublicationYear "1995" @default.
- W2427497595 type Work @default.
- W2427497595 sameAs 2427497595 @default.
- W2427497595 citedByCount "5" @default.
- W2427497595 countsByYear W24274975952018 @default.
- W2427497595 countsByYear W24274975952020 @default.
- W2427497595 countsByYear W24274975952022 @default.
- W2427497595 crossrefType "journal-article" @default.
- W2427497595 hasAuthorship W2427497595A5001320577 @default.
- W2427497595 hasAuthorship W2427497595A5003476187 @default.
- W2427497595 hasAuthorship W2427497595A5012591748 @default.
- W2427497595 hasAuthorship W2427497595A5016292547 @default.
- W2427497595 hasAuthorship W2427497595A5020338238 @default.
- W2427497595 hasAuthorship W2427497595A5077517618 @default.
- W2427497595 hasConcept C16005928 @default.
- W2427497595 hasConcept C181389837 @default.
- W2427497595 hasConcept C2775874440 @default.
- W2427497595 hasConcept C2777071850 @default.
- W2427497595 hasConcept C2779548794 @default.
- W2427497595 hasConcept C2781297407 @default.
- W2427497595 hasConcept C71924100 @default.
- W2427497595 hasConcept C98274493 @default.
- W2427497595 hasConceptScore W2427497595C16005928 @default.
- W2427497595 hasConceptScore W2427497595C181389837 @default.
- W2427497595 hasConceptScore W2427497595C2775874440 @default.
- W2427497595 hasConceptScore W2427497595C2777071850 @default.
- W2427497595 hasConceptScore W2427497595C2779548794 @default.
- W2427497595 hasConceptScore W2427497595C2781297407 @default.
- W2427497595 hasConceptScore W2427497595C71924100 @default.
- W2427497595 hasConceptScore W2427497595C98274493 @default.
- W2427497595 hasIssue "3" @default.
- W2427497595 hasLocation W24274975951 @default.
- W2427497595 hasOpenAccess W2427497595 @default.
- W2427497595 hasPrimaryLocation W24274975951 @default.
- W2427497595 hasRelatedWork W1672347066 @default.
- W2427497595 hasRelatedWork W1888776632 @default.
- W2427497595 hasRelatedWork W2006558422 @default.
- W2427497595 hasRelatedWork W2048123993 @default.
- W2427497595 hasRelatedWork W2052710268 @default.
- W2427497595 hasRelatedWork W2077695407 @default.
- W2427497595 hasRelatedWork W2096272275 @default.
- W2427497595 hasRelatedWork W2896452734 @default.
- W2427497595 hasRelatedWork W4224090648 @default.
- W2427497595 hasRelatedWork W2560036503 @default.
- W2427497595 hasVolume "75" @default.
- W2427497595 isParatext "false" @default.
- W2427497595 isRetracted "false" @default.
- W2427497595 magId "2427497595" @default.
- W2427497595 workType "article" @default.