Matches in SemOpenAlex for { <https://semopenalex.org/work/W2427608832> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2427608832 endingPage "4" @default.
- W2427608832 startingPage "611" @default.
- W2427608832 abstract "Extracellular proteases (proteinases, endopeptidases) are usually synthesized as larger precursors containing a signal sequence in the N-terminal part of their molecule. The signal sequence contains a sequence composed of hydrophobic amino acids which facilitate the transport of the polypeptide through membranes of the secretory apparatus. Extracellular proteinases play an important role in reproduction and spreading of tumor cells and in tissue remodelling in addition to their function in digestion food proteins. Intracellular proteinases are mostly localized in the cytoplasm and in specialized organelles (lysosomes) but are present also in nuclei and in mitochondria. They degrade or modify cell proteins and are thus involved in protein turnover which is necessary for cell viability. Intracellular proteinases are important components of the cell defense system which protects the cell against the effect of different stress factors by removing damaged and nonfunctional proteins. They modify different proteins and are thus involved in virus reproduction because some proteins are synthesized as nonfunctional virus precursors. Intracellular proteinases also play a role in the cell cycle control and in cytodifferentiation. Rather complex proteolytic enzymes were found even in very primitive organisms (archebacteria)." @default.
- W2427608832 created "2016-06-24" @default.
- W2427608832 creator A5063001146 @default.
- W2427608832 date "1995-10-04" @default.
- W2427608832 modified "2023-09-25" @default.
- W2427608832 title "[Proteolytic enzymes in cell physiology and pathophysiology]." @default.
- W2427608832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7585872" @default.
- W2427608832 hasPublicationYear "1995" @default.
- W2427608832 type Work @default.
- W2427608832 sameAs 2427608832 @default.
- W2427608832 citedByCount "0" @default.
- W2427608832 crossrefType "journal-article" @default.
- W2427608832 hasAuthorship W2427608832A5063001146 @default.
- W2427608832 hasConcept C104317684 @default.
- W2427608832 hasConcept C10858879 @default.
- W2427608832 hasConcept C1491633281 @default.
- W2427608832 hasConcept C167625842 @default.
- W2427608832 hasConcept C168240541 @default.
- W2427608832 hasConcept C181199279 @default.
- W2427608832 hasConcept C182220744 @default.
- W2427608832 hasConcept C190062978 @default.
- W2427608832 hasConcept C28406088 @default.
- W2427608832 hasConcept C3019223276 @default.
- W2427608832 hasConcept C55493867 @default.
- W2427608832 hasConcept C79879829 @default.
- W2427608832 hasConcept C86803240 @default.
- W2427608832 hasConcept C95444343 @default.
- W2427608832 hasConceptScore W2427608832C104317684 @default.
- W2427608832 hasConceptScore W2427608832C10858879 @default.
- W2427608832 hasConceptScore W2427608832C1491633281 @default.
- W2427608832 hasConceptScore W2427608832C167625842 @default.
- W2427608832 hasConceptScore W2427608832C168240541 @default.
- W2427608832 hasConceptScore W2427608832C181199279 @default.
- W2427608832 hasConceptScore W2427608832C182220744 @default.
- W2427608832 hasConceptScore W2427608832C190062978 @default.
- W2427608832 hasConceptScore W2427608832C28406088 @default.
- W2427608832 hasConceptScore W2427608832C3019223276 @default.
- W2427608832 hasConceptScore W2427608832C55493867 @default.
- W2427608832 hasConceptScore W2427608832C79879829 @default.
- W2427608832 hasConceptScore W2427608832C86803240 @default.
- W2427608832 hasConceptScore W2427608832C95444343 @default.
- W2427608832 hasIssue "19" @default.
- W2427608832 hasLocation W24276088321 @default.
- W2427608832 hasOpenAccess W2427608832 @default.
- W2427608832 hasPrimaryLocation W24276088321 @default.
- W2427608832 hasRelatedWork W150207168 @default.
- W2427608832 hasRelatedWork W18184129 @default.
- W2427608832 hasRelatedWork W1999639022 @default.
- W2427608832 hasRelatedWork W2013237352 @default.
- W2427608832 hasRelatedWork W2427608832 @default.
- W2427608832 hasRelatedWork W263755546 @default.
- W2427608832 hasRelatedWork W2940195999 @default.
- W2427608832 hasRelatedWork W2986232785 @default.
- W2427608832 hasRelatedWork W4285818717 @default.
- W2427608832 hasRelatedWork W86732265 @default.
- W2427608832 hasVolume "134" @default.
- W2427608832 isParatext "false" @default.
- W2427608832 isRetracted "false" @default.
- W2427608832 magId "2427608832" @default.
- W2427608832 workType "article" @default.