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• W2427876887 abstract "Loss of appetite and weight are frequently observed at altitudes above 5000m. However, the pathophysiology behind changes in body composition at extreme altitude is still not fuIly understood. Proper acclimatization to altitude and high caloric intake minimizes, but can not completely prevent significant weight loss under the influence of hypobaric hypoxia. The discovery of leptin in 1994 has initiated a new research area investigating molecular networks that connect peripheral organs with the central nervous system to sense and regulate energy intake as weIl as energy expenditure. Since then, a whole microcosm of new hormones, neurotransmitters and receptors has been discovered and studied with respect to body weight contro!. Those agents include neuropeptide Y (NPY), agouti-related protein (AGRP), melanocortin receptors (MC-R), cocaine-amphetamine regulated transcript (CART), pro­ opiomelanocortin (POMC), orexin A and B (hypocretins), melanin­ concentrating hormone (MCH) and ghrelin (endogenous ligand of the growth hormone secretagogue receptor). This overview will introduce the current concepts of the molecular control of energy homeostasis and attempt to reexamine the effects of altitude on appetite and body composition in light of these concepts. An overview of studies on changes of appetite and body composition at high altitude will be foIlowed by the presentation of recent data on changes of endocrine parameters at hypobaric hypoxia that could be involved in the pathophysiology ofweight loss." @default.
• W2427876887 created "2016-06-24" @default.
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• W2427876887 date "2001-01-01" @default.
• W2427876887 modified "2023-09-27" @default.
• W2427876887 title "Chapter 16 Weight loss at high altitude" @default.
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