Matches in SemOpenAlex for { <https://semopenalex.org/work/W2428104117> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2428104117 endingPage "89" @default.
- W2428104117 startingPage "179" @default.
- W2428104117 abstract "The biosynthesis of sulfated mucin in gastric tissue was investigated in cold-stress and indomethacin (CSI)-induced gastric ulcer models. To examine the synthesis of gastric sulfated mucin, [35S]H2SO4 (sulfate) incorporation into gastric mucin was measured. The treatment of CSI inhibited the incorporation of [35S]sulfate after 2 hr. The gastric acid hypersecretion or the formation of severe ulcer was observed at 1 or 4 hr after the CSI-treatment, respectively. Pibutidine hydrochloride (IT-066), a novel H2-receptor antagonist, (0.3 mg/kg, s.c.) inhibited the formation of ulcer and reversed the inhibition of mucin sulfation by the CSI-treatment, whereas atropine sulfate, a muscarinic receptor antagonist, (1.0 mg/kg, s.c.) did not inhibit the development of ulcer nor decrease in the mucin sulfation at 6 hr after the CSI-treatment. IT-066 inhibited the total acid output (T.A.O.) due to the reduction of the acidity in the gastric juice, whereas atropine inhibited the T.A.O. due to that of the volume. These results indicated that a different mode of action between IT-066 and atropine on gastric acid secretion influences their actions in the incorporation of [35S]sulfate and the formation of ulcer in the CSI-treated rat. Therefore, it is considered that the reduction of biosynthesis of gastric sulfated mucin following acid hypersecretion may be responsible for the formation of gastric ulcer." @default.
- W2428104117 created "2016-06-24" @default.
- W2428104117 creator A5015482488 @default.
- W2428104117 creator A5030726308 @default.
- W2428104117 creator A5055771560 @default.
- W2428104117 creator A5062175137 @default.
- W2428104117 creator A5088760818 @default.
- W2428104117 date "1997-11-01" @default.
- W2428104117 modified "2023-09-23" @default.
- W2428104117 title "Effect of cold-stress and indomethacin on the biosynthesis of gastric sulfated mucin in rats." @default.
- W2428104117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9467826" @default.
- W2428104117 hasPublicationYear "1997" @default.
- W2428104117 type Work @default.
- W2428104117 sameAs 2428104117 @default.
- W2428104117 citedByCount "1" @default.
- W2428104117 crossrefType "journal-article" @default.
- W2428104117 hasAuthorship W2428104117A5015482488 @default.
- W2428104117 hasAuthorship W2428104117A5030726308 @default.
- W2428104117 hasAuthorship W2428104117A5055771560 @default.
- W2428104117 hasAuthorship W2428104117A5062175137 @default.
- W2428104117 hasAuthorship W2428104117A5088760818 @default.
- W2428104117 hasConcept C126322002 @default.
- W2428104117 hasConcept C134018914 @default.
- W2428104117 hasConcept C155138218 @default.
- W2428104117 hasConcept C170493617 @default.
- W2428104117 hasConcept C178790620 @default.
- W2428104117 hasConcept C179264091 @default.
- W2428104117 hasConcept C185592680 @default.
- W2428104117 hasConcept C2775859210 @default.
- W2428104117 hasConcept C2776885963 @default.
- W2428104117 hasConcept C2777504413 @default.
- W2428104117 hasConcept C2778343803 @default.
- W2428104117 hasConcept C2779422922 @default.
- W2428104117 hasConcept C2781443798 @default.
- W2428104117 hasConcept C33789571 @default.
- W2428104117 hasConcept C49039625 @default.
- W2428104117 hasConcept C55493867 @default.
- W2428104117 hasConcept C71924100 @default.
- W2428104117 hasConcept C98274493 @default.
- W2428104117 hasConceptScore W2428104117C126322002 @default.
- W2428104117 hasConceptScore W2428104117C134018914 @default.
- W2428104117 hasConceptScore W2428104117C155138218 @default.
- W2428104117 hasConceptScore W2428104117C170493617 @default.
- W2428104117 hasConceptScore W2428104117C178790620 @default.
- W2428104117 hasConceptScore W2428104117C179264091 @default.
- W2428104117 hasConceptScore W2428104117C185592680 @default.
- W2428104117 hasConceptScore W2428104117C2775859210 @default.
- W2428104117 hasConceptScore W2428104117C2776885963 @default.
- W2428104117 hasConceptScore W2428104117C2777504413 @default.
- W2428104117 hasConceptScore W2428104117C2778343803 @default.
- W2428104117 hasConceptScore W2428104117C2779422922 @default.
- W2428104117 hasConceptScore W2428104117C2781443798 @default.
- W2428104117 hasConceptScore W2428104117C33789571 @default.
- W2428104117 hasConceptScore W2428104117C49039625 @default.
- W2428104117 hasConceptScore W2428104117C55493867 @default.
- W2428104117 hasConceptScore W2428104117C71924100 @default.
- W2428104117 hasConceptScore W2428104117C98274493 @default.
- W2428104117 hasIssue "2" @default.
- W2428104117 hasLocation W24281041171 @default.
- W2428104117 hasOpenAccess W2428104117 @default.
- W2428104117 hasPrimaryLocation W24281041171 @default.
- W2428104117 hasRelatedWork W1457058838 @default.
- W2428104117 hasRelatedWork W1981346819 @default.
- W2428104117 hasRelatedWork W1982314959 @default.
- W2428104117 hasRelatedWork W2009051567 @default.
- W2428104117 hasRelatedWork W2059584879 @default.
- W2428104117 hasRelatedWork W2063741409 @default.
- W2428104117 hasRelatedWork W2078271276 @default.
- W2428104117 hasRelatedWork W2081320142 @default.
- W2428104117 hasRelatedWork W2148873872 @default.
- W2428104117 hasRelatedWork W2428104117 @default.
- W2428104117 hasVolume "98" @default.
- W2428104117 isParatext "false" @default.
- W2428104117 isRetracted "false" @default.
- W2428104117 magId "2428104117" @default.
- W2428104117 workType "article" @default.