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- W2428110003 abstract "There is a trend in the parenteral industry to move from the use of elastomeric closures which are washed, siliconized, dried and sterilized in-house at the pharmaceutical manufacturers' site to pre-prepared closures purchased from the closure supplier. This preparation can consist of washing to reduce particle-load and bioburden, siliconization, placement in ready-to-sterilize bags and may eventually extend to sterilization by steam autoclave or gamma irradiation. Since silicone oil lubrication is critical to the processability/machinability of closures, research was designed to investigate this phenomenon in closures prepared using the Westar RS (Ready-to-Sterilize) process. This paper presents the data gathered in a study of the characteristic of silicone absorption into elastomeric closures under accelerated conditions. Variables such as silicone viscosity, rubber formulation, effect of sterilization and others are considered." @default.
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- W2428110003 date "1998-04-29" @default.
- W2428110003 modified "2023-09-25" @default.
- W2428110003 title "Silicone absorption of elastomeric closures--an accelerated study." @default.
- W2428110003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9542410" @default.
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