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- W2428156964 abstract "Contact inhibition of growth is the prop- erty in vitro whose loss is most closely correlated with tu- morigenicity in vivo. A contact-inhibited melanocytic cell line produces a diffusible protein-containing factor ca- pable of restoring contact inhibition of cell division to highly malignant hamster melanocytes. Its addition to sub- confluent cultures of the malignant cells is followed by the obligatory acquisition, at confluence, of the contact-in- hibited state. Cultures are flat, oriented, and fibroblast- like, and show a 55% decrease in saturation density with no loss of viability. The effect is reversible. Present in con- ditioned media of cultures of the contact-inhibited melan- ocytic cell line, isolated by column chromatography on Sephadex G-200, the factor appears to be of high molec- ular weight. Activity is preserved in aqueous solutions at 4? for at least 8 weeks, but is destroyed by repeated freeze- thawing or by treatment with Pronase. This newly recognized contact-inhibitory factor may be a prototype for a more general and fundamental mecha- nism for regulation of normal cell-cell interactions. It is the first cell-elaborated factor to be isolated that is capable of restoring the capacity for contact inhibition of growth to malignant cells." @default.
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- W2428156964 date "2016-01-01" @default.
- W2428156964 modified "2023-09-27" @default.
- W2428156964 title "A Diffusible Factor Restoring Contact In} Malignant Melanocytes" @default.
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