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• W2428909062 abstract "Abstract Objectives Orodispersible films (ODF) were formulated to facilitate tetrabenazine (TBZ) administration to paediatric population for the treatment of hyperkinetic movement disorders. Methods ODF were obtained by solvent casting/evaporation method using four different polymers (HPMC, PVP, pullulan and HEC). Physicochemical, mechanical and biopharmaceutical characterizations as well as API state in ODF by thermal analysis were investigated to define and compare formulations. ODF stability was also monitored during 6 months to follow evolution of properties. Key findings Analyses at T0 showed few differences between formulations: results of physicochemical and mechanical characterizations were almost similar for each formulation and TBZ appeared at the amorphous state in all cases. ODF delivery system allowed a major improvement of TBZ dissolution profile in buccal conditions compared with pure drug. However, after 3 and 6 months of stability, a TBZ recrystallization occurred for formulations based on PVP and HEC associated with a decrease of drug release in saliva conditions. Conclusions HPMC-ODF (F1) appeared as the best formulation. Indeed, physicochemical, mechanical and biopharmaceutical characteristic remained intact. In addition, TBZ remained in amorphous state during stability study." @default.
• W2428909062 created "2016-06-24" @default.
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• W2428909062 date "2016-09-27" @default.
• W2428909062 modified "2023-09-27" @default.
• W2428909062 title "Formulation of orodispersible films for paediatric therapy: investigation of feasibility and stability for tetrabenazine as drug model" @default.
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• W2428909062 doi "https://doi.org/10.1111/jphp.12627" @default.
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