Matches in SemOpenAlex for { <https://semopenalex.org/work/W2429109663> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2429109663 endingPage "8" @default.
- W2429109663 startingPage "134" @default.
- W2429109663 abstract "The aim of this study was to evaluate the skin permeability of anemonin, which was extracted from the Chinese herb weilingxian, and its potency of relieving the inflammation caused by rheumatoid arthritis (RA). To optimize the formulation, the solubility of anemonin in water and selected concentration of ethanol-water vehicles was determined. The effect of ethanol on the permeation of anemonin through human skin was then studied. Additionally, the influences of hydroxypropyl methylcellulose E50 (HPMC) and Carbomer 934 in different concentrations on the permeation of drug were investigated. Finally, the anti-inflammatory effect of the optimized formulation was assessed by murine model of xylene-induced ear edema. The results showed that the solubility and transdermal permeation of anemonin in ethanol-water vehicles linearly depended on the ethanol concentration. The combination of 30% ethanol and 3% Azone had a synergistic enhancement effect and was therefore selected for gel preparation. The 0.14% anemonin gel prepared with 1% HPMC exhibited the highest transdermal flux. The xylene-induced ear edema inhibitory rate of the optimized formulation was 48.85%. The results indicated that transdermal administration of anemonin is a potential modality for combating inflammation caused by RA." @default.
- W2429109663 created "2016-06-24" @default.
- W2429109663 creator A5012587305 @default.
- W2429109663 creator A5040680674 @default.
- W2429109663 creator A5041939160 @default.
- W2429109663 creator A5051241137 @default.
- W2429109663 creator A5063689514 @default.
- W2429109663 date "2016-03-01" @default.
- W2429109663 modified "2023-09-27" @default.
- W2429109663 title "Skin permeation profile and anti-inflammatory effect of anemonin extracted from weilingxian." @default.
- W2429109663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27183707" @default.
- W2429109663 hasPublicationYear "2016" @default.
- W2429109663 type Work @default.
- W2429109663 sameAs 2429109663 @default.
- W2429109663 citedByCount "5" @default.
- W2429109663 countsByYear W24291096632021 @default.
- W2429109663 countsByYear W24291096632022 @default.
- W2429109663 countsByYear W24291096632023 @default.
- W2429109663 crossrefType "journal-article" @default.
- W2429109663 hasAuthorship W2429109663A5012587305 @default.
- W2429109663 hasAuthorship W2429109663A5040680674 @default.
- W2429109663 hasAuthorship W2429109663A5041939160 @default.
- W2429109663 hasAuthorship W2429109663A5051241137 @default.
- W2429109663 hasAuthorship W2429109663A5063689514 @default.
- W2429109663 hasConcept C155574463 @default.
- W2429109663 hasConcept C178790620 @default.
- W2429109663 hasConcept C181389837 @default.
- W2429109663 hasConcept C185592680 @default.
- W2429109663 hasConcept C205679159 @default.
- W2429109663 hasConcept C2776005048 @default.
- W2429109663 hasConcept C2780161600 @default.
- W2429109663 hasConcept C2781227287 @default.
- W2429109663 hasConcept C41625074 @default.
- W2429109663 hasConcept C43617362 @default.
- W2429109663 hasConcept C50670333 @default.
- W2429109663 hasConcept C55493867 @default.
- W2429109663 hasConcept C71924100 @default.
- W2429109663 hasConcept C98274493 @default.
- W2429109663 hasConceptScore W2429109663C155574463 @default.
- W2429109663 hasConceptScore W2429109663C178790620 @default.
- W2429109663 hasConceptScore W2429109663C181389837 @default.
- W2429109663 hasConceptScore W2429109663C185592680 @default.
- W2429109663 hasConceptScore W2429109663C205679159 @default.
- W2429109663 hasConceptScore W2429109663C2776005048 @default.
- W2429109663 hasConceptScore W2429109663C2780161600 @default.
- W2429109663 hasConceptScore W2429109663C2781227287 @default.
- W2429109663 hasConceptScore W2429109663C41625074 @default.
- W2429109663 hasConceptScore W2429109663C43617362 @default.
- W2429109663 hasConceptScore W2429109663C50670333 @default.
- W2429109663 hasConceptScore W2429109663C55493867 @default.
- W2429109663 hasConceptScore W2429109663C71924100 @default.
- W2429109663 hasConceptScore W2429109663C98274493 @default.
- W2429109663 hasIssue "3" @default.
- W2429109663 hasLocation W24291096631 @default.
- W2429109663 hasOpenAccess W2429109663 @default.
- W2429109663 hasPrimaryLocation W24291096631 @default.
- W2429109663 hasRelatedWork W1995998779 @default.
- W2429109663 hasRelatedWork W2340913197 @default.
- W2429109663 hasRelatedWork W2350307116 @default.
- W2429109663 hasRelatedWork W2352552813 @default.
- W2429109663 hasRelatedWork W2361592800 @default.
- W2429109663 hasRelatedWork W2361919333 @default.
- W2429109663 hasRelatedWork W2367073981 @default.
- W2429109663 hasRelatedWork W2369552726 @default.
- W2429109663 hasRelatedWork W2393327971 @default.
- W2429109663 hasRelatedWork W2429109663 @default.
- W2429109663 hasVolume "71" @default.
- W2429109663 isParatext "false" @default.
- W2429109663 isRetracted "false" @default.
- W2429109663 magId "2429109663" @default.
- W2429109663 workType "article" @default.