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- W2429120950 abstract "AbstractThe purpose of the study was to investigate self-nanoemulsifying drug delivery system (SNEDDS) as potential delivery system for poorly water soluble drug Lurasidone (LUR). SNEDDS was formulated using oil (Anise oil) surfactant (Tween® 80), and co-surfactant (Polyethyleneglycol-600). Z-average size, PDI and in-vitro drug release were considered to screen and optimize the composition of liquid-SNEDDS. Following emulsification, the optimized formulation was selected to have the smallest mean particle size and highest absolute zeta potential, which would yield stable emulsion. Scanning electron microscopy, X-ray powder diffraction studies confirmed that there was no crystalline drug in Solid-SNEDDS. Fourier transform infrared (FTIR) spectroscopy study revealed that there was no measurable chemical interaction of drug with the carrier. There was no significance difference in zeta average, zeta potential, and release profile of developed formulation before and after stability study. Both Liquid-SNEDDS a..." @default.
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- W2429120950 date "2016-03-03" @default.
- W2429120950 modified "2023-09-25" @default.
- W2429120950 title "Improved Solubility and Dissolution Release Profile of Lurasidone by Solid Self-Nanoemulsifying Drug Delivery System" @default.
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- W2429120950 doi "https://doi.org/10.1080/22297928.2016.1164075" @default.
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