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• W2429382166 abstract "ISEE-646 Objective: Epidemiologic studies suggest that pesticide exposure may increase the risk of specific types of cancer. In Brazil, where the use of pesticide grows rapidly, studies that evaluate the impact of pesticide exposure on cancer incidence and mortality are very scarce. In this study, we evaluated the degree of correlation between pesticide sales in 11 Brazilian states in 1985 and cancer mortality rates during 1996–1998. Materials and Methods: Information of all cancer deaths occurred in men, 30 to 69 years old, from 1996 to 1998 were collected from National Mortality System. Age-adjusted cancer mortality rates were calculated using population census estimates. Spearman's correlation coefficients were then obtained for pesticide sales (per capita) and the following types of cancer: prostate, soft tissue, larynx, leukemia, lip, esophagus, lung, pancreas, bladder, liver, testis, stomach, brain, non-Hodgkin lymphoma, and multiple myeloma. In addition, states were divided into 3 groups according to their level of pesticide use (tertiles) and cancer mortality rate ratios (MRR) were then calculated using first tertile as reference. Results: Pesticide sales showed high correlation with cancer mortality rates for prostate (r = 0.78; P = 0.004), soft tissue (r = 0.75; P = 0.007), larynx (r = 0.73; P = 0.011), and leukemia (r = 0.70; P = 0.016). We also observed moderate correlation between pesticide sales and mortality rates for the cancers of lip (r = 0.65; P = 0.030), esophagus (r = 0.62; P = 0.043), pancreas (r = 0.57; P = 0.066), bladder (r = 0.57; P = 0.066), liver (r = 0.54; P = 0.089), testis (r = 0.53; P = 0.096), and stomach (r = 0.50; P = 0.117). For most of specific sites, cancer mortality rates were significantly higher in states of moderate (2nd tertile) and high (3rd tertile) pesticide use, with MRR ranging from 1.11 to 5.61. Conclusions: Moderate-to-high correlation coefficients between pesticide sales and several types of cancer were observed. The results suggest that population exposure to pesticides in the 1980s in some Brazilian States may have been associated with the development of selected types of cancer observed a decade later." @default.
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• W2429382166 date "2007-09-01" @default.
• W2429382166 modified "2023-09-26" @default.
• W2429382166 title "Correlation Between Pesticide Sales and Specific-Site Cancer Mortality Rates in Brazil" @default.
• W2429382166 doi "https://doi.org/10.1097/01.ede.0000276801.85344.df" @default.
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