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- W24294505 abstract "Publisher Summary This chapter discusses a study to analyze the action of piribedil on presynaptic dopamine receptors at postganglionic sympathetic nerve terminals. In this study, mongrel dogs of either sex weighing 15–21 kg were anaesthetized with pentobarbital (30 mg/kg i.v.). The trachea was intubated and the dogs were ventilated with a Mark VII Bird respirator. Blood pressure was monitored by means of a catheter introduced into the abdominal aorta via the femoral artery and connected to a Statham P 23 Db pressure transducer on a Brusch 440 recorder. The stimulation of the postganglionic sympathetic nerve was performed using a T Hugo Sachs stimulator. A polyethylene catheter was inserted into the abdominal aorta. It was found that the electrical stimulation of the lumbar sympathetic chain induced a frequency dependent increase in the perfusion pressure of the hindlimb. The average increases ranged from 25 ± 3 mmHg at 0.5 Hz to 120 ± 11 mmHg at 16 Hz. Piribedil (1 mg/kg i.v.) inhibited the response to nerve stimulation and this inhibitory effect was more effective at lower frequencies." @default.
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- W24294505 date "1979-01-01" @default.
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- W24294505 title "Action of Piribedil on Presynaptic Dopamine Receptors at Postganglionic Sympathetic Nerve Terminals" @default.
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- W24294505 doi "https://doi.org/10.1016/b978-0-08-023189-1.50072-7" @default.
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