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• W2429771129 abstract "Abstract Megalocytivirus is a DNA virus that is highly infectious in a wide variety of marine and freshwater fish, including Japanese flounder ( Paralichthys olivaceus ), a flatfish that is farmed worldwide. However, the infection mechanism of megalocytivirus remains largely unknown. In this study, we investigated the function of a flounder microRNA, pol-miR-731, in virus-host interaction. We found that pol-miR-731 was induced in expression by megalocytivirus and promoted viral replication at the early infection stage. In vivo and in vitro studies revealed that pol-miR-731 (i) specifically suppresses the expression of interferon regulatory factor 7 (IRF7) and cellular tumor antigen p53 in a manner that depended on the integrity of the pol-miR-731 complementary sequences in the 3′ untranslated regions of IRF7 and p53, (ii) disrupts megalocytivirus-induced Type I interferon response through IRF7, (iii) inhibits megalocytivirus-induced splenocyte apoptosis and cell cycle arrest through p53. Furthermore, overexpression of IRF7 and p53 abolished both the inhibitory effects of pol-miR-731 on these biological processes and its stimulatory effect on viral replication. These results disclosed a novel evasion mechanism of megalocytivirus mediated by a host miRNA. This study also provides the first evidence that a virus-induced host miRNA can facilitate viral infection by simultaneously suppressing several antiviral pathways." @default.
• W2429771129 created "2016-06-24" @default.
• W2429771129 creator A5047191391 @default.
• W2429771129 creator A5049415248 @default.
• W2429771129 creator A5080542773 @default.
• W2429771129 date "2016-06-17" @default.
• W2429771129 modified "2023-10-17" @default.
• W2429771129 title "pol-miR-731, a teleost miRNA upregulated by megalocytivirus, negatively regulates virus-induced type I interferon response, apoptosis and cell cycle arrest" @default.
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• W2429771129 doi "https://doi.org/10.1038/srep28354" @default.
• W2429771129 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4911600" @default.
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• W2429771129 hasPublicationYear "2016" @default.
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