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- W2429892868 abstract "Heparin cofactor II is a glycoprotein present in human plasma at a concentration of approximately 1.2 microM. It inhibits thrombin by forming a stable, 1:1 complex with the protease. The rate of complex formation is increased approximately 1,000-fold by heparin or dermatan sulfate. Heparin cofactor II appears to be the only thrombin inhibitor in plasma that can be activated by dermatan sulfate. Platelet factor 4 abolishes the activation of heparin cofactor II by dermatan sulfate, but plasma histidine-rich glycoprotein does not. Heparin cofactor II is activated by dermatan sulfate oligosaccharides that are at least 12-14 sugar residues in length and contain a high-affinity binding site for the inhibitor protein." @default.
- W2429892868 created "2016-06-24" @default.
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- W2429892868 date "1984-01-01" @default.
- W2429892868 modified "2023-09-23" @default.
- W2429892868 title "Activation of heparin cofactor II by heparin and dermatan sulfate." @default.
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