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- W243012767 abstract "Abstract To investigate the microstructural mechanisms of decreasing microvascular permeability induced by the enhancement of intraendothelial adenosine 3’,5’-cyclic monophosphate (cAMP) levels, we extended the previous analytical model developed by Fu et al. (J. Biomech. Eng., 1994) for the interendothelial cleft to include multiple junction strands in the cleft and an interface between the surface glycocalyx layer and the cleft entrance. Based on the electron microscopic observation by Adamson et al. (Am. J. Physiol., 1998), that elevation of intracellular cAMP levels would increase number of tight junction strands, numerical method was applied to test the case in which there are two junction strands in the cleft and there are large discontinuous breaks and a small continuous slit in each strand. Results from this two-junction-strand and two-pore model can successfully account for the experimental data for the decreased permeability to water (Adamson et al. Am. J. Physiol., 1998), small and intermediate-sized solutes (Fu et al., Am. J. Physiol., 1998) by cAMP." @default.
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- W243012767 date "2001-11-11" @default.
- W243012767 modified "2023-09-25" @default.
- W243012767 title "A Model for the Structural Mechanisms in the Regulation of Microvessel Permeability by cAMP" @default.
- W243012767 doi "https://doi.org/10.1115/imece2001/htd-24416" @default.
- W243012767 hasPublicationYear "2001" @default.
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