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- W2430265218 abstract "This study tests the hypothesis that improved muscle salvage is possible by markedly reducing the ionic calcium (Ca++) of the reperfusate (<250 μmol/L) and adding a calcium channel–blocking drug (diltiazem). Preliminary pilot studies showed (1) that a 20-minute infusion of markedly hypocalcemic substrate-enriched blood cardioplegic solution (<250 μmol/L Ca++) did not affect left ventricular function adversely and (2) that a 150 to 250 μmol/L substrate-enriched blood cardioplegic solution, delivered during total vented bypass with diltiazem, 300 μg/kg body weight, produced the most consistent functional recovery and the least histochemical evidence of damage (triphenyltetrazolium chloride nonstaining) after 2 hours of regional ischemia. Experimental studies of 2 hours of regional ischemia were followed by either regional normocalcemic (1000 to 1200 μmol/L) blood cardioplegic reperfusion in bypassed hearts, with or without diltiazem, or hypocalcemic (150 to 150 μmol/L) blood cardioplegic reperfusion with diltiazem for 20 minutes. Results showed that hypocalcemic blood cardioplegic solution with diltiazem produced superior recovery of systolic shortening (58 % versus 11 % systolic shortening, p < 0.05) and limitation of histochemical damage (11% versus 54%, p < 0.05), in comparison with normocalcemic blood cardioplegic solution without diltiazem. These studies suggest that modifying the regional reperfusate by markedly reducing ionic calcium levels and adding calcium channel-blocking drugs is safe and may improve myocardial salvage more than using substrate-enriched blood cardioplegic solution alone." @default.
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- W2430265218 date "1986-09-01" @default.
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- W2430265218 title "STUDIES OF CONTROLLED REPERFUSION AFTER ISCHEMIA" @default.
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- W2430265218 doi "https://doi.org/10.1016/s0022-5223(19)36507-9" @default.
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