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- W2430336324 abstract "To investigate the release model of insoluble drug carbamazepine (CBM) based on HPMC matrix tablets.CBM release profile from matrices and HPMC erosion rate were determined.The mathematical model by matrix erosion rate and drug release from HPMC K15M were established for the fractional HPMC and CBM released as M(P(t))/M(P(infinity))=-[0.8095ln((t))+1.2775]Meq((-0.0622t-0.305)) and M(d(t))/M(d(infinity))=-[0.1891t-0.1294]Meq(-0.9326). In comparison with the data of HPMC K4M matrix erosion and CBM release from HPMC K4M matrices, theoretical value agreed well with experimental data.The two mathematical models can be satisfactorily applied to insoluble drug release, which is governed by matrix erosion." @default.
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- W2430336324 date "2004-05-01" @default.
- W2430336324 modified "2023-09-26" @default.
- W2430336324 title "[Investigation on release model of insoluble drug in hydroxypropyl methycellulose matrix tablets]." @default.
- W2430336324 doi "https://doi.org/10.3785/j.issn.1008-9292.2004.03.011" @default.
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