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• W2430684625 abstract "Abstract Background We hypothesized that radiotherapy (RT) would improve both local and regional control with Merkel cell carcinoma of the head and neck. Methods A single‐institution institutional review board‐approved study was performed including 113 patients with nonmetastatic Merkel cell carcinoma of the head and neck. Postoperative RT was delivered to the primary tumor bed (71.7% cases) ± draining lymphatics (33.3% RT cases). Results Postoperative local RT was associated with improved local control (3‐year actuarial local control 89.4% vs 68.1%; p = .005; Cox hazard ratio [HR] 0.18; 95% confidence interval [CI] = 0.06–0.55; p = .002). Similarly, regional RT was associated with improved regional control (3‐year actuarial regional control 95.0% vs 66.7%; p = .008; Cox HR = 0.09; 95% CI = 0.01–0.69; p = .02). Regional RT played an important role for both clinical node‐negative patients (3‐year regional control 100% vs 44.7%; p = .03) and clinical/pathological node‐positive patients (3‐year regional control 90.9% vs 55.6%; p = .047). Conclusion Local RT was beneficial for all patients with Merkel cell carcinoma of the head and neck, whereas regional RT was beneficial for clinical node‐negative and clinical/pathological node‐positive patients. © 2016 Wiley Periodicals, Inc. Head Neck 39: 48–55, 2017" @default.
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• W2430684625 date "2016-06-14" @default.
• W2430684625 modified "2023-10-16" @default.
• W2430684625 title "Improved local and regional control with radiotherapy for Merkel cell carcinoma of the head and neck" @default.
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• W2430684625 doi "https://doi.org/10.1002/hed.24527" @default.
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