Matches in SemOpenAlex for { <https://semopenalex.org/work/W2430796697> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2430796697 endingPage "62" @default.
- W2430796697 startingPage "1957" @default.
- W2430796697 abstract "To elucidate the role of epidermal growth factor (EGF) in the maintenance and repair of airway epithelial cells in adult humans, we investigated immunohistochemically whether EGF receptor (EGFR) is expressed in these cells. In the present study, we employed the AMeX method (Sato et al., 1986) for tissue preparation. We first examined the expression of EGFR in peripheral lung tissue and bronchial tissue obtained at surgery from thirteen adult patients with lung carcinoma. The results showed that there was no positive staining for EGFR in the bronchial surface epithelium, bronchial glandular cells, bronchiolar epithelium or alveolar lining cells. There was also no expression of EGFR in cells comprising areas of basal cell hyperplasia and epidermoid metaplasia in the bronchus, or alveolar cell hyperplasia and columnar cell metaplasia in fibrotic lung tissue. Second, we examined the expression of EGFR in regenerating distal airway epithelial cells, which were experimentally produced by xenotransplantation of human lung tissue into the subcutaneous tissue of nude mice. There was also no expression of EGFR at any stage of regeneration from one week through six weeks after the transplantation. It is concluded that EGFR is not expressed, at least at an immunohistochemically detectable level, by airway epithelial cells of adult humans, not only in the quiescent state but also under conditions in which epithelial cells are stimulated to replicate. Thus, it appears unlikely that the EGF/EGFR system plays an important role in either maintenance or repair of airway epithelial cells in adult humans." @default.
- W2430796697 created "2016-06-24" @default.
- W2430796697 creator A5040985959 @default.
- W2430796697 creator A5047524684 @default.
- W2430796697 creator A5061584319 @default.
- W2430796697 creator A5078595637 @default.
- W2430796697 creator A5079217790 @default.
- W2430796697 creator A5081649988 @default.
- W2430796697 date "1992-11-01" @default.
- W2430796697 modified "2023-10-12" @default.
- W2430796697 title "[Expression of epidermal growth factor receptor in adult human airway epithelium--application of AMeX method]." @default.
- W2430796697 cites W1518606691 @default.
- W2430796697 cites W1605302012 @default.
- W2430796697 cites W1972018493 @default.
- W2430796697 cites W1973323865 @default.
- W2430796697 cites W2049636096 @default.
- W2430796697 cites W2145310996 @default.
- W2430796697 cites W2171246715 @default.
- W2430796697 cites W2255378067 @default.
- W2430796697 cites W2322325722 @default.
- W2430796697 cites W2401140324 @default.
- W2430796697 cites W2409593516 @default.
- W2430796697 cites W2410168404 @default.
- W2430796697 cites W2418834630 @default.
- W2430796697 cites W2443929111 @default.
- W2430796697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1484435" @default.
- W2430796697 hasPublicationYear "1992" @default.
- W2430796697 type Work @default.
- W2430796697 sameAs 2430796697 @default.
- W2430796697 citedByCount "0" @default.
- W2430796697 crossrefType "journal-article" @default.
- W2430796697 hasAuthorship W2430796697A5040985959 @default.
- W2430796697 hasAuthorship W2430796697A5047524684 @default.
- W2430796697 hasAuthorship W2430796697A5061584319 @default.
- W2430796697 hasAuthorship W2430796697A5078595637 @default.
- W2430796697 hasAuthorship W2430796697A5079217790 @default.
- W2430796697 hasAuthorship W2430796697A5081649988 @default.
- W2430796697 hasConcept C126322002 @default.
- W2430796697 hasConcept C142724271 @default.
- W2430796697 hasConcept C170493617 @default.
- W2430796697 hasConcept C204232928 @default.
- W2430796697 hasConcept C2776362946 @default.
- W2430796697 hasConcept C2777562237 @default.
- W2430796697 hasConcept C2777714996 @default.
- W2430796697 hasConcept C2778981785 @default.
- W2430796697 hasConcept C2779357193 @default.
- W2430796697 hasConcept C2779438470 @default.
- W2430796697 hasConcept C529295009 @default.
- W2430796697 hasConcept C71924100 @default.
- W2430796697 hasConcept C87568996 @default.
- W2430796697 hasConceptScore W2430796697C126322002 @default.
- W2430796697 hasConceptScore W2430796697C142724271 @default.
- W2430796697 hasConceptScore W2430796697C170493617 @default.
- W2430796697 hasConceptScore W2430796697C204232928 @default.
- W2430796697 hasConceptScore W2430796697C2776362946 @default.
- W2430796697 hasConceptScore W2430796697C2777562237 @default.
- W2430796697 hasConceptScore W2430796697C2777714996 @default.
- W2430796697 hasConceptScore W2430796697C2778981785 @default.
- W2430796697 hasConceptScore W2430796697C2779357193 @default.
- W2430796697 hasConceptScore W2430796697C2779438470 @default.
- W2430796697 hasConceptScore W2430796697C529295009 @default.
- W2430796697 hasConceptScore W2430796697C71924100 @default.
- W2430796697 hasConceptScore W2430796697C87568996 @default.
- W2430796697 hasIssue "11" @default.
- W2430796697 hasLocation W24307966971 @default.
- W2430796697 hasOpenAccess W2430796697 @default.
- W2430796697 hasPrimaryLocation W24307966971 @default.
- W2430796697 hasRelatedWork W1689793612 @default.
- W2430796697 hasRelatedWork W1977210574 @default.
- W2430796697 hasRelatedWork W2032349273 @default.
- W2430796697 hasRelatedWork W2046869232 @default.
- W2430796697 hasRelatedWork W2144686096 @default.
- W2430796697 hasRelatedWork W2156923220 @default.
- W2430796697 hasRelatedWork W2339623916 @default.
- W2430796697 hasRelatedWork W2430796697 @default.
- W2430796697 hasRelatedWork W2443512328 @default.
- W2430796697 hasRelatedWork W64337094 @default.
- W2430796697 hasVolume "30" @default.
- W2430796697 isParatext "false" @default.
- W2430796697 isRetracted "false" @default.
- W2430796697 magId "2430796697" @default.
- W2430796697 workType "article" @default.