FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2431369884> ?p ?o ?g. }

• W2431369884 endingPage "1071" @default.
• W2431369884 startingPage "1057" @default.
• W2431369884 abstract "The spectrum of alcoholic liver disease (ALD) is a major cause of mortality with limited therapies available. Because alcohol targets numerous signaling pathways in hepatocytes and in immune cells, the identification of a master regulatory target that modulates multiple signaling processes is attractive. In this report, we assessed the role of spleen tyrosine kinase (SYK), a nonreceptor tyrosine kinase, which has a central modulatory role in multiple proinflammatory signaling pathways involved in the pathomechanism of ALD. Using mouse disease models that represent various phases in the progression of human ALD, we found that alcohol, in all of these models, induced SYK activation in the liver, both in hepatocytes and liver mononuclear cells. Furthermore, significant SYK activation also occurred in liver samples and peripheral blood mononuclear cells of patients with ALD/alcoholic hepatitis compared to controls. Functional inhibition of SYK activation in vivo abrogated alcohol-induced hepatic neutrophil infiltration, resident immune cell activation, as well as inflammasome and extracellular signal-regulated kinase 1 and 2-mediated nuclear factor kappa B activation in mice. Strikingly, inhibition of SYK activation diminished alcohol-induced hepatic steatosis and interferon regulatory factor 3-mediated apoptosis.Our data demonstrate a novel, functional, and multicellular role for SYK phosphorylation in modulating immune cell-driven liver inflammation, hepatocyte cell death, and steatosis at different stages of ALD. These novel findings highlight SYK as a potential multifunctional target in the treatment of alcoholic steatohepatitis. (Hepatology 2016;64:1057-1071)." @default.
• W2431369884 created "2016-06-24" @default.
• W2431369884 creator A5006482005 @default.
• W2431369884 creator A5014200307 @default.
• W2431369884 creator A5030438113 @default.
• W2431369884 creator A5051675326 @default.
• W2431369884 creator A5052184953 @default.
• W2431369884 creator A5064442250 @default.
• W2431369884 creator A5075528793 @default.
• W2431369884 creator A5080461804 @default.
• W2431369884 creator A5085358451 @default.
• W2431369884 creator A5088666506 @default.
• W2431369884 date "2016-07-22" @default.
• W2431369884 modified "2023-09-30" @default.
• W2431369884 title "Inhibition of spleen tyrosine kinase activation ameliorates inflammation, cell death, and steatosis in alcoholic liver disease" @default.
• W2431369884 cites W1543963511 @default.
• W2431369884 cites W1822606120 @default.
• W2431369884 cites W1903259758 @default.
• W2431369884 cites W1945214665 @default.
• W2431369884 cites W1963665686 @default.
• W2431369884 cites W1970663543 @default.
• W2431369884 cites W1975752601 @default.
• W2431369884 cites W1985434991 @default.
• W2431369884 cites W1994190235 @default.
• W2431369884 cites W2002511115 @default.
• W2431369884 cites W2005857763 @default.
• W2431369884 cites W2008189791 @default.
• W2431369884 cites W2011473183 @default.
• W2431369884 cites W2017341404 @default.
• W2431369884 cites W2017730825 @default.
• W2431369884 cites W2024933805 @default.
• W2431369884 cites W2025355874 @default.
• W2431369884 cites W2029570646 @default.
• W2431369884 cites W2034801500 @default.
• W2431369884 cites W2050069950 @default.
• W2431369884 cites W2058682780 @default.
• W2431369884 cites W2060637877 @default.
• W2431369884 cites W2072510538 @default.
• W2431369884 cites W2075675512 @default.
• W2431369884 cites W2079673140 @default.
• W2431369884 cites W2083367491 @default.
• W2431369884 cites W2083457154 @default.
• W2431369884 cites W2095726706 @default.
• W2431369884 cites W2097500515 @default.
• W2431369884 cites W2101935191 @default.
• W2431369884 cites W2107005309 @default.
• W2431369884 cites W2121448896 @default.
• W2431369884 cites W2132158567 @default.
• W2431369884 cites W2132940521 @default.
• W2431369884 cites W2133276049 @default.
• W2431369884 cites W2136354950 @default.
• W2431369884 cites W2140695384 @default.
• W2431369884 cites W2155029398 @default.
• W2431369884 cites W2158056092 @default.
• W2431369884 cites W2158314747 @default.
• W2431369884 cites W2158928008 @default.
• W2431369884 cites W2164777978 @default.
• W2431369884 cites W2165436546 @default.
• W2431369884 cites W2167132971 @default.
• W2431369884 cites W2168181266 @default.
• W2431369884 cites W2328023807 @default.
• W2431369884 cites W4211166276 @default.
• W2431369884 cites W4237588511 @default.
• W2431369884 cites W64186310 @default.
• W2431369884 cites W853047119 @default.
• W2431369884 cites W994061229 @default.
• W2431369884 doi "https://doi.org/10.1002/hep.28680" @default.
• W2431369884 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5033691" @default.
• W2431369884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27302565" @default.
• W2431369884 hasPublicationYear "2016" @default.
• W2431369884 type Work @default.
• W2431369884 sameAs 2431369884 @default.
• W2431369884 citedByCount "41" @default.
• W2431369884 countsByYear W24313698842017 @default.
• W2431369884 countsByYear W24313698842018 @default.
• W2431369884 countsByYear W24313698842019 @default.
• W2431369884 countsByYear W24313698842020 @default.
• W2431369884 countsByYear W24313698842021 @default.
• W2431369884 countsByYear W24313698842022 @default.
• W2431369884 countsByYear W24313698842023 @default.
• W2431369884 crossrefType "journal-article" @default.
• W2431369884 hasAuthorship W2431369884A5006482005 @default.
• W2431369884 hasAuthorship W2431369884A5014200307 @default.
• W2431369884 hasAuthorship W2431369884A5030438113 @default.
• W2431369884 hasAuthorship W2431369884A5051675326 @default.
• W2431369884 hasAuthorship W2431369884A5052184953 @default.
• W2431369884 hasAuthorship W2431369884A5064442250 @default.
• W2431369884 hasAuthorship W2431369884A5075528793 @default.
• W2431369884 hasAuthorship W2431369884A5080461804 @default.
• W2431369884 hasAuthorship W2431369884A5085358451 @default.
• W2431369884 hasAuthorship W2431369884A5088666506 @default.
• W2431369884 hasBestOaLocation W24313698842 @default.
• W2431369884 hasConcept C126322002 @default.
• W2431369884 hasConcept C164027704 @default.
• W2431369884 hasConcept C203014093 @default.
• W2431369884 hasConcept C2776914184 @default.
• W2431369884 hasConcept C2777214474 @default.
• W2431369884 hasConcept C2777575235 @default.

• next