Matches in SemOpenAlex for { <https://semopenalex.org/work/W2431605961> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2431605961 endingPage "8" @default.
- W2431605961 startingPage "24" @default.
- W2431605961 abstract "Sl/Sld mice are a unique animal model for studying platelet production in that they sustain normal platelet mass despite reduced marrow activity. The aim of this study was to determine if the compensatory mechanisms operating in these mice could be augmented by further reducing bone marrow activity with the drug 5-fluorouracil (5-FU), known to induce a strong stimulatory effect on platelet production. The platelet recovery in Sl/Sld mice after 5-FU administration contrasted that found in their normal littermates. Sl/Sld mice did not display the sustained thrombocytosis that was observed in +/+ mice between days 10 and 14. Platelet number was elevated in Sl/Sld mice at day 20, when the marrow megakaryocyte compartment had normalized. A significant increase in marrow megakaryocyte number and size was observed at days 8 and 11 in both +/+ and Sl/Sld mice after 5-FU administration. The data suggest that the increase in megakaryocyte size and number following 5-FU treatment was not able to significantly contribute to a sustained rebound thrombocytosis at the time of increased marrow megakaryocytopoiesis. It is concluded that the already compromised marrow of Sl/Sld mice is able to respond to the damage invoked by 5-FU to produce larger than normal megakaryocytes. In contrast to normal mice (+/+ littermates), the increase in marrow megakaryocytopoiesis observed does not lead to a thrombocytosis, indicating that platelet production and release in Sl/Sld mice cannot be further amplified by a strong marrow stimulation." @default.
- W2431605961 created "2016-06-24" @default.
- W2431605961 creator A5004870950 @default.
- W2431605961 creator A5007366107 @default.
- W2431605961 creator A5018733739 @default.
- W2431605961 creator A5090840116 @default.
- W2431605961 date "1991-01-01" @default.
- W2431605961 modified "2023-09-23" @default.
- W2431605961 title "Compensatory mechanisms in platelet production: the response of Sl/Sld mice to 5-fluorouracil." @default.
- W2431605961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1989891" @default.
- W2431605961 hasPublicationYear "1991" @default.
- W2431605961 type Work @default.
- W2431605961 sameAs 2431605961 @default.
- W2431605961 citedByCount "3" @default.
- W2431605961 crossrefType "journal-article" @default.
- W2431605961 hasAuthorship W2431605961A5004870950 @default.
- W2431605961 hasAuthorship W2431605961A5007366107 @default.
- W2431605961 hasAuthorship W2431605961A5018733739 @default.
- W2431605961 hasAuthorship W2431605961A5090840116 @default.
- W2431605961 hasConcept C109159458 @default.
- W2431605961 hasConcept C126322002 @default.
- W2431605961 hasConcept C134018914 @default.
- W2431605961 hasConcept C16685009 @default.
- W2431605961 hasConcept C203014093 @default.
- W2431605961 hasConcept C24998067 @default.
- W2431605961 hasConcept C2776958478 @default.
- W2431605961 hasConcept C2777863708 @default.
- W2431605961 hasConcept C2777918643 @default.
- W2431605961 hasConcept C2779705218 @default.
- W2431605961 hasConcept C2779788118 @default.
- W2431605961 hasConcept C2780007613 @default.
- W2431605961 hasConcept C28328180 @default.
- W2431605961 hasConcept C71924100 @default.
- W2431605961 hasConcept C86803240 @default.
- W2431605961 hasConcept C89560881 @default.
- W2431605961 hasConcept C95444343 @default.
- W2431605961 hasConceptScore W2431605961C109159458 @default.
- W2431605961 hasConceptScore W2431605961C126322002 @default.
- W2431605961 hasConceptScore W2431605961C134018914 @default.
- W2431605961 hasConceptScore W2431605961C16685009 @default.
- W2431605961 hasConceptScore W2431605961C203014093 @default.
- W2431605961 hasConceptScore W2431605961C24998067 @default.
- W2431605961 hasConceptScore W2431605961C2776958478 @default.
- W2431605961 hasConceptScore W2431605961C2777863708 @default.
- W2431605961 hasConceptScore W2431605961C2777918643 @default.
- W2431605961 hasConceptScore W2431605961C2779705218 @default.
- W2431605961 hasConceptScore W2431605961C2779788118 @default.
- W2431605961 hasConceptScore W2431605961C2780007613 @default.
- W2431605961 hasConceptScore W2431605961C28328180 @default.
- W2431605961 hasConceptScore W2431605961C71924100 @default.
- W2431605961 hasConceptScore W2431605961C86803240 @default.
- W2431605961 hasConceptScore W2431605961C89560881 @default.
- W2431605961 hasConceptScore W2431605961C95444343 @default.
- W2431605961 hasIssue "1" @default.
- W2431605961 hasLocation W24316059611 @default.
- W2431605961 hasOpenAccess W2431605961 @default.
- W2431605961 hasPrimaryLocation W24316059611 @default.
- W2431605961 hasRelatedWork W161941179 @default.
- W2431605961 hasRelatedWork W2029138997 @default.
- W2431605961 hasRelatedWork W2039398324 @default.
- W2431605961 hasRelatedWork W2056918958 @default.
- W2431605961 hasRelatedWork W2103632011 @default.
- W2431605961 hasRelatedWork W2431605961 @default.
- W2431605961 hasRelatedWork W247127784 @default.
- W2431605961 hasRelatedWork W2899880294 @default.
- W2431605961 hasRelatedWork W4235041219 @default.
- W2431605961 hasRelatedWork W4248876388 @default.
- W2431605961 hasVolume "19" @default.
- W2431605961 isParatext "false" @default.
- W2431605961 isRetracted "false" @default.
- W2431605961 magId "2431605961" @default.
- W2431605961 workType "article" @default.