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- W2431841849 abstract "Fibrosis is characterised by an exuberant wound healing response and the major cell type responsible is the myofibroblast. The myofibroblast is typified by excessive ECM production and contractile activity and is demarcated by alpha-smooth muscle actin expression. What has recently come to light is that the activation of the fibroblast to myofibroblast may be under epigenetic control, specifically methylation. Methylation of DNA is a conserved mechanism to precisely regulate gene expression in a specific context. Hypermethylation leads to gene repression and hypomethylation results in gene induction. Methylation abnormalities have recently been uncovered in fibrosis, both organ specific and widespread fibrosis. The fact that these methylation changes are rapid and reversible lends themselves amenable to therapeutic intervention. This review considers the role of methylation in fibrosis and the activation of the myofibroblasts and how this could be targeted for fibrosis. Fibrosis is of course currently intractable to therapeutics and is a leading cause of morbidity and mortality and is an urgent unmet clinical need." @default.
- W2431841849 created "2016-06-24" @default.
- W2431841849 creator A5011531890 @default.
- W2431841849 creator A5059598344 @default.
- W2431841849 date "2016-09-01" @default.
- W2431841849 modified "2023-10-12" @default.
- W2431841849 title "DNA methylation in fibrosis" @default.
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- W2431841849 cites W1975077655 @default.
- W2431841849 cites W1976980117 @default.
- W2431841849 cites W1980325398 @default.
- W2431841849 cites W1981615091 @default.
- W2431841849 cites W1988094624 @default.
- W2431841849 cites W1989386822 @default.
- W2431841849 cites W1992061722 @default.
- W2431841849 cites W1997453048 @default.
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- W2431841849 cites W2018512856 @default.
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- W2431841849 cites W2038449573 @default.
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- W2431841849 doi "https://doi.org/10.1016/j.ejcb.2016.06.003" @default.
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