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- W2432009973 abstract "Epidermal growth factor (EGF) activates a well characterized signal transduction system in human A431 epidermoid carcinoma cells, which leads to rapid and transient expression of the c-fos proto-oncogene. In order to investigate the influence of altered gravity on EGF-induced signal transduction, we have studied the EGF-induced c-fos expression under simulated hypo- and hypergravity conditions. In this report we show that EGF-induced fos expression is decreased under simulated hypogravity conditions, while hypergravity has a stimulatory effect on EGF-induced fos expression. These results show that the EGF-activated signal transduction system is influenced by gravity, and that gravity exerts its effects already in the early phases of the signal transduction cascade." @default.
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- W2432009973 date "1991-01-01" @default.
- W2432009973 modified "2023-09-23" @default.
- W2432009973 title "Epidermal growth factor-induced expression of c-fos is influenced by altered gravity conditions." @default.
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