FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2432328780> ?p ?o ?g. }

• W2432328780 abstract "The emergence of multi-drug and extensive drug resistance of microbes to antibiotics poses a great threat to human health. Although drug repurposing is a promising solution for accelerating the drug development process, its application to anti-infectious drug discovery is limited by the scope of existing phenotype-, ligand-, or target-based methods. In this paper we introduce a new computational strategy to determine the genome-wide molecular targets of bioactive compounds in both human and bacterial genomes. Our method is based on the use of a novel algorithm, ligand Enrichment of Network Topological Similarity (ligENTS), to map the chemical universe to its global pharmacological space. ligENTS outperforms the state-of-the-art algorithms in identifying novel drug-target relationships. Furthermore, we integrate ligENTS with our structural systems biology platform to identify drug repurposing opportunities via target similarity profiling. Using this integrated strategy, we have identified novel P. falciparum targets of drug-like active compounds from the Malaria Box, and suggest that a number of approved drugs may be active against malaria. This study demonstrates the potential of an integrative chemical genomics and structural systems biology approach to drug repurposing." @default.
• W2432328780 created "2016-06-24" @default.
• W2432328780 creator A5027920014 @default.
• W2432328780 creator A5064879302 @default.
• W2432328780 creator A5066245750 @default.
• W2432328780 creator A5075833022 @default.
• W2432328780 creator A5085425476 @default.
• W2432328780 date "2013-11-01" @default.
• W2432328780 modified "2023-09-27" @default.
• W2432328780 title "ANTI-INFECTIOUS DRUG REPURPOSING USING AN INTEGRATED CHEMICAL GENOMICS AND STRUCTURAL SYSTEMS BIOLOGY APPROACH" @default.
• W2432328780 cites W1996682530 @default.
• W2432328780 cites W2224337562 @default.
• W2432328780 doi "https://doi.org/10.1142/9789814583220_0014" @default.
• W2432328780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6322395" @default.
• W2432328780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24297541" @default.
• W2432328780 hasPublicationYear "2013" @default.
• W2432328780 type Work @default.
• W2432328780 sameAs 2432328780 @default.
• W2432328780 citedByCount "11" @default.
• W2432328780 countsByYear W24323287802015 @default.
• W2432328780 countsByYear W24323287802016 @default.
• W2432328780 countsByYear W24323287802017 @default.
• W2432328780 countsByYear W24323287802018 @default.
• W2432328780 countsByYear W24323287802019 @default.
• W2432328780 countsByYear W24323287802021 @default.
• W2432328780 crossrefType "proceedings-article" @default.
• W2432328780 hasAuthorship W2432328780A5027920014 @default.
• W2432328780 hasAuthorship W2432328780A5064879302 @default.
• W2432328780 hasAuthorship W2432328780A5066245750 @default.
• W2432328780 hasAuthorship W2432328780A5075833022 @default.
• W2432328780 hasAuthorship W2432328780A5085425476 @default.
• W2432328780 hasBestOaLocation W24323287802 @default.
• W2432328780 hasConcept C103637391 @default.
• W2432328780 hasConcept C104317684 @default.
• W2432328780 hasConcept C111919701 @default.
• W2432328780 hasConcept C141231307 @default.
• W2432328780 hasConcept C152662350 @default.
• W2432328780 hasConcept C187191949 @default.
• W2432328780 hasConcept C18903297 @default.
• W2432328780 hasConcept C189206191 @default.
• W2432328780 hasConcept C203014093 @default.
• W2432328780 hasConcept C2778048844 @default.
• W2432328780 hasConcept C2780035454 @default.
• W2432328780 hasConcept C41008148 @default.
• W2432328780 hasConcept C519536355 @default.
• W2432328780 hasConcept C54355233 @default.
• W2432328780 hasConcept C60644358 @default.
• W2432328780 hasConcept C70721500 @default.
• W2432328780 hasConcept C74187038 @default.
• W2432328780 hasConcept C86803240 @default.
• W2432328780 hasConcept C98274493 @default.
• W2432328780 hasConcept C99726746 @default.
• W2432328780 hasConceptScore W2432328780C103637391 @default.
• W2432328780 hasConceptScore W2432328780C104317684 @default.
• W2432328780 hasConceptScore W2432328780C111919701 @default.
• W2432328780 hasConceptScore W2432328780C141231307 @default.
• W2432328780 hasConceptScore W2432328780C152662350 @default.
• W2432328780 hasConceptScore W2432328780C187191949 @default.
• W2432328780 hasConceptScore W2432328780C18903297 @default.
• W2432328780 hasConceptScore W2432328780C189206191 @default.
• W2432328780 hasConceptScore W2432328780C203014093 @default.
• W2432328780 hasConceptScore W2432328780C2778048844 @default.
• W2432328780 hasConceptScore W2432328780C2780035454 @default.
• W2432328780 hasConceptScore W2432328780C41008148 @default.
• W2432328780 hasConceptScore W2432328780C519536355 @default.
• W2432328780 hasConceptScore W2432328780C54355233 @default.
• W2432328780 hasConceptScore W2432328780C60644358 @default.
• W2432328780 hasConceptScore W2432328780C70721500 @default.
• W2432328780 hasConceptScore W2432328780C74187038 @default.
• W2432328780 hasConceptScore W2432328780C86803240 @default.
• W2432328780 hasConceptScore W2432328780C98274493 @default.
• W2432328780 hasConceptScore W2432328780C99726746 @default.
• W2432328780 hasLocation W24323287801 @default.
• W2432328780 hasLocation W24323287802 @default.
• W2432328780 hasLocation W24323287803 @default.
• W2432328780 hasOpenAccess W2432328780 @default.
• W2432328780 hasPrimaryLocation W24323287801 @default.
• W2432328780 hasRelatedWork W1900205071 @default.
• W2432328780 hasRelatedWork W1966527984 @default.
• W2432328780 hasRelatedWork W1975441976 @default.
• W2432328780 hasRelatedWork W1984054151 @default.
• W2432328780 hasRelatedWork W1989590412 @default.
• W2432328780 hasRelatedWork W1992407562 @default.
• W2432328780 hasRelatedWork W2016914833 @default.
• W2432328780 hasRelatedWork W2020132970 @default.
• W2432328780 hasRelatedWork W2062941476 @default.
• W2432328780 hasRelatedWork W2076764146 @default.
• W2432328780 hasRelatedWork W2098178401 @default.
• W2432328780 hasRelatedWork W2109120098 @default.
• W2432328780 hasRelatedWork W2111213181 @default.
• W2432328780 hasRelatedWork W2113072832 @default.
• W2432328780 hasRelatedWork W2138512826 @default.
• W2432328780 hasRelatedWork W2144267044 @default.
• W2432328780 hasRelatedWork W2154896031 @default.
• W2432328780 hasRelatedWork W2155157373 @default.
• W2432328780 hasRelatedWork W2208662536 @default.
• W2432328780 hasRelatedWork W2794313083 @default.
• W2432328780 isParatext "false" @default.
• W2432328780 isRetracted "false" @default.
• W2432328780 magId "2432328780" @default.

• next