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• W2432453090 abstract "Fast neuronal network oscillations in the gamma frequency band (30-100 Hz) occur in various cortex regions, require timed synaptic excitation and inhibition with glutamate and GABA, respectively, and are associated with higher brain functions such as sensory perception, attentional selection and memory formation. However, little is known about energy and ion homeostasis during the gamma oscillation. Recent studies addressed this topic in slices of the rodent hippocampus. Methods with high spatial and temporal resolution were applied, such as electrophysiological recordings of local field potential (LFP) and extracellular potassium concentration ([K+]o), live-cell fluorescence imaging of NAD(P)H and FAD (cellular redox state), and monitoring of the interstitial partial oxygen pressure (pO2) in depth profiles with microsensor electrodes, including mathematical modelling. The main findings are: (i) gamma oscillations are associated with high oxygen consumption rate and significant changes in the cellular redox state, indicating rapid adaptations in glycolysis and oxidative phosphorylation. (ii) Gamma oscillations are accompanied by fluctuating elevations in [K+]o of less than 0.5 mmol/L from baseline, likely reflecting effective K+-uptake mechanisms of neuron and astrocyte compartments. (iii) Gamma oscillations are exquisitely sensitive to metabolic stress induced by lowering oxygen availability or by pharmacological inhibition of the mitochondrial respiratory chain. These findings reflect precise cellular adaptations to maintain ATP, ion and neurotransmitter homeostasis and thus neural excitability and synaptic signaling during gamma oscillations. Conversely, the exquisite sensitivity of gamma oscillations to metabolic stress might significantly contribute the exceptional vulnerability of higher brain functions in brain disease." @default.
• W2432453090 created "2016-06-24" @default.
• W2432453090 creator A5000308900 @default.
• W2432453090 creator A5013270051 @default.
• W2432453090 creator A5076590784 @default.
• W2432453090 creator A5086306688 @default.
• W2432453090 date "2016-06-16" @default.
• W2432453090 modified "2023-09-27" @default.
• W2432453090 title "Energy and Potassium Ion Homeostasis during Gamma Oscillations" @default.
• W2432453090 cites W1136751452 @default.
• W2432453090 cites W120845308 @default.
• W2432453090 cites W1509344561 @default.
• W2432453090 cites W1524937662 @default.
• W2432453090 cites W1533823519 @default.
• W2432453090 cites W1582215827 @default.
• W2432453090 cites W1605560027 @default.
• W2432453090 cites W1653233231 @default.
• W2432453090 cites W1770958704 @default.
• W2432453090 cites W1793516482 @default.
• W2432453090 cites W1917708460 @default.
• W2432453090 cites W1956327946 @default.
• W2432453090 cites W1961513473 @default.
• W2432453090 cites W1967497524 @default.
• W2432453090 cites W1969801391 @default.
• W2432453090 cites W1972432206 @default.
• W2432453090 cites W1973275441 @default.
• W2432453090 cites W1973783515 @default.
• W2432453090 cites W1974653682 @default.
• W2432453090 cites W1977873342 @default.
• W2432453090 cites W1979566060 @default.
• W2432453090 cites W1983939506 @default.
• W2432453090 cites W1983967034 @default.
• W2432453090 cites W1984660568 @default.
• W2432453090 cites W1984695443 @default.
• W2432453090 cites W1987777969 @default.
• W2432453090 cites W1988436577 @default.
• W2432453090 cites W1990973912 @default.
• W2432453090 cites W1992521533 @default.
• W2432453090 cites W1995101735 @default.
• W2432453090 cites W1996805613 @default.
• W2432453090 cites W1998139571 @default.
• W2432453090 cites W1998776259 @default.
• W2432453090 cites W1999204179 @default.
• W2432453090 cites W2001406143 @default.
• W2432453090 cites W2001954021 @default.
• W2432453090 cites W2004976934 @default.
• W2432453090 cites W2005609503 @default.
• W2432453090 cites W2006129707 @default.
• W2432453090 cites W2006209961 @default.
• W2432453090 cites W2007031766 @default.
• W2432453090 cites W2008027377 @default.
• W2432453090 cites W2009782005 @default.
• W2432453090 cites W2010087363 @default.
• W2432453090 cites W2012974904 @default.
• W2432453090 cites W2013186737 @default.
• W2432453090 cites W2020832630 @default.
• W2432453090 cites W2020848121 @default.
• W2432453090 cites W2021551330 @default.
• W2432453090 cites W2023876378 @default.
• W2432453090 cites W2024422476 @default.
• W2432453090 cites W2024675123 @default.
• W2432453090 cites W2024875626 @default.
• W2432453090 cites W2025339443 @default.
• W2432453090 cites W2025462332 @default.
• W2432453090 cites W2026062374 @default.
• W2432453090 cites W2026777646 @default.
• W2432453090 cites W2029565084 @default.
• W2432453090 cites W2030286287 @default.
• W2432453090 cites W2030492864 @default.
• W2432453090 cites W2030670571 @default.
• W2432453090 cites W2032402125 @default.
• W2432453090 cites W2033642739 @default.
• W2432453090 cites W2034004233 @default.
• W2432453090 cites W2034965090 @default.
• W2432453090 cites W2038845124 @default.
• W2432453090 cites W2041359982 @default.
• W2432453090 cites W2042422091 @default.
• W2432453090 cites W2044487387 @default.
• W2432453090 cites W2045458651 @default.
• W2432453090 cites W2047347093 @default.
• W2432453090 cites W2048528277 @default.
• W2432453090 cites W2049681765 @default.
• W2432453090 cites W2050065612 @default.
• W2432453090 cites W2051342221 @default.
• W2432453090 cites W2051966316 @default.
• W2432453090 cites W2052792709 @default.
• W2432453090 cites W2054341407 @default.
• W2432453090 cites W2054365519 @default.
• W2432453090 cites W2055075694 @default.
• W2432453090 cites W2056038034 @default.
• W2432453090 cites W2056633409 @default.
• W2432453090 cites W2058610977 @default.
• W2432453090 cites W2058698189 @default.
• W2432453090 cites W2058929671 @default.
• W2432453090 cites W2061058549 @default.
• W2432453090 cites W2063439808 @default.
• W2432453090 cites W2063786734 @default.
• W2432453090 cites W2065459990 @default.
• W2432453090 cites W2066410470 @default.
• W2432453090 cites W2067842357 @default.

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