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- W2433050399 abstract "The bacterial metabolism of the primary bile acid, taurocholate, was studied during enterohepatic circulation in 18 patients with ileal disorders, 5 patients with disorders which involved the duodenojejunum primarily, and 4 student volunteers. Following intravenous injection of taurocholate-24-14C, the chemical composition of the total 14C radioactivity was determined in serial samples of duodenal fluid. Bacterial modification of taurocholate contributed materially to the maintenance of enterohepatic circulation of bile acids in normal subjects. The major transformation was deconjugation per se, resulting in the presence of reconjugated trihydroxy bile acids in the enterohepatic space. Deconjugation and 7-a-dehydroxylation, producing conjugates of deoxycholic acid, occurred to a lesser degree. The presence of intestinal pathology which caused “stasis” or obstruction appeared to favor the growth of organisms capable of deconjugation and 7-α-dehydroxylation, thereby resulting in a greater proportion of secondary dihydroxy bile acids present as conjugates of deoxycholic acid. The importance of an intact ileal transport mechanism in the maintenance of enterohepatic circulation of both primary and secondary bile acids is re-emphasized." @default.
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- W2433050399 date "1970-10-01" @default.
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- W2433050399 title "Bacterial Modification of Taurocholate During Enterohepatic Recirculation in Normal Man and Patients With Small Intestinal Disease" @default.
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- W2433050399 doi "https://doi.org/10.1016/s0016-5085(19)33709-6" @default.
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