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• W2433133915 endingPage "7759" @default.
• W2433133915 startingPage "7750" @default.
• W2433133915 abstract "The purpose of the study was to investigate the protective effects of the ethanol extract of Diospyros kaki (EEDK) persimmon leaves to study N-methyl-N-nitrosourea (MNU)-induced retinal degeneration in mice. EEDK was orally administered after MNU injection. Retinal layer thicknesses were significantly increased in the EEDK-treated group compared with the MNU-treated group. The outer nuclear layer was preserved in the retinas of EEDK-treated mice. Moreover, EEDK treatment reduced the MNU-dependent up-regulation of glial fibrillary acidic protein (GFAP) and nestin expression in Müller and astrocyte cells. EEDK treatment also inhibited MNU-dependent down-regulation of rhodopsin expression. Quercetin exposure significantly attenuated the negative effects of H2O2 in R28 cells, suggesting that quercetin can act in an antioxidative capacity. Thus, EEDK may be considered as an agent for treating or preventing degenerative retinal diseases, such as retinitis pigmentosa and age-related macular degeneration." @default.
• W2433133915 created "2016-06-24" @default.
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• W2433133915 date "2015-08-19" @default.
• W2433133915 modified "2023-10-02" @default.
• W2433133915 title "Leaves of Persimmon (<i>Diospyros kaki</i> Thunb.) Ameliorate <i>N</i>-Methyl-<i>N</i>-nitrosourea (MNU)-Induced Retinal Degeneration in Mice" @default.
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• W2433133915 doi "https://doi.org/10.1021/acs.jafc.5b02578" @default.
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• W2433133915 hasPublicationYear "2015" @default.
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