FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2433139937> ?p ?o ?g. }

• W2433139937 endingPage "9508" @default.
• W2433139937 startingPage "9499" @default.
• W2433139937 abstract "Asparaginase reduces the levels of asparagine in blood, which is an essential amino acid for the proliferation of lymphoblastic malign cells. Asparaginase converts asparagine into aspartic acid and ammonia. The accumulation of ammonia in the bloodstream leads to hyperammonemia, described as one of the most significant side effects of asparaginase therapy. Therefore, there is a need for asparaginase formulations with the potential to reduce hyperammonemia. We incorporated 2 % of therapeutic enzyme in albumin-based capsules. The presence of asparaginase in the interface of bovine serum albumin (BSA) capsules showed the ability to hydrolyze the asparagine and retain the forming ammonia at the surface of the capsules. The incorporation of Poloxamer 407 in the capsule formulation further increased the ratio aspartic acid/ammonia from 1.92 to 2.46 (and 1.10 from the free enzyme), decreasing the levels of free ammonia. This capacity to retain ammonia can be due to electrostatic interactions and retention of ammonia at the surface of the capsules. The developed BSA/asparaginase capsules did not cause significant cytotoxic effect on mouse leukemic macrophage cell line RAW 264.7. The new BSA/asparaginase capsules could potentially be used in the treatment of acute lymphoblastic leukemia preventing hyperammonemia associated with acute lymphoblastic leukemia (ALL) treatment with asparaginase." @default.
• W2433139937 created "2016-06-24" @default.
• W2433139937 creator A5024848049 @default.
• W2433139937 creator A5026308231 @default.
• W2433139937 creator A5032796498 @default.
• W2433139937 creator A5039023571 @default.
• W2433139937 creator A5044116003 @default.
• W2433139937 date "2016-06-17" @default.
• W2433139937 modified "2023-10-13" @default.
• W2433139937 title "Albumin/asparaginase capsules prepared by ultrasound to retain ammonia" @default.
• W2433139937 cites W1553128399 @default.
• W2433139937 cites W1683632289 @default.
• W2433139937 cites W185484821 @default.
• W2433139937 cites W1964807748 @default.
• W2433139937 cites W1971341070 @default.
• W2433139937 cites W1988937184 @default.
• W2433139937 cites W1991377526 @default.
• W2433139937 cites W1994577742 @default.
• W2433139937 cites W1999494112 @default.
• W2433139937 cites W2003807724 @default.
• W2433139937 cites W2005725119 @default.
• W2433139937 cites W2008283467 @default.
• W2433139937 cites W2011110927 @default.
• W2433139937 cites W2012523531 @default.
• W2433139937 cites W2019412904 @default.
• W2433139937 cites W2020424034 @default.
• W2433139937 cites W2035309334 @default.
• W2433139937 cites W2041998484 @default.
• W2433139937 cites W2054038164 @default.
• W2433139937 cites W2069873775 @default.
• W2433139937 cites W2084879398 @default.
• W2433139937 cites W2094296511 @default.
• W2433139937 cites W2102131116 @default.
• W2433139937 cites W2113512182 @default.
• W2433139937 cites W2163862575 @default.
• W2433139937 cites W2167062390 @default.
• W2433139937 cites W4241364882 @default.
• W2433139937 doi "https://doi.org/10.1007/s00253-016-7668-4" @default.
• W2433139937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27314846" @default.
• W2433139937 hasPublicationYear "2016" @default.
• W2433139937 type Work @default.
• W2433139937 sameAs 2433139937 @default.
• W2433139937 citedByCount "9" @default.
• W2433139937 countsByYear W24331399372019 @default.
• W2433139937 countsByYear W24331399372020 @default.
• W2433139937 countsByYear W24331399372021 @default.
• W2433139937 countsByYear W24331399372023 @default.
• W2433139937 crossrefType "journal-article" @default.
• W2433139937 hasAuthorship W2433139937A5024848049 @default.
• W2433139937 hasAuthorship W2433139937A5026308231 @default.
• W2433139937 hasAuthorship W2433139937A5032796498 @default.
• W2433139937 hasAuthorship W2433139937A5039023571 @default.
• W2433139937 hasAuthorship W2433139937A5044116003 @default.
• W2433139937 hasBestOaLocation W24331399372 @default.
• W2433139937 hasConcept C126322002 @default.
• W2433139937 hasConcept C181199279 @default.
• W2433139937 hasConcept C185592680 @default.
• W2433139937 hasConcept C2775895851 @default.
• W2433139937 hasConcept C2776125364 @default.
• W2433139937 hasConcept C2776382133 @default.
• W2433139937 hasConcept C2778461978 @default.
• W2433139937 hasConcept C2778904437 @default.
• W2433139937 hasConcept C2781099255 @default.
• W2433139937 hasConcept C2781208047 @default.
• W2433139937 hasConcept C2909962599 @default.
• W2433139937 hasConcept C515207424 @default.
• W2433139937 hasConcept C55493867 @default.
• W2433139937 hasConcept C71924100 @default.
• W2433139937 hasConcept C86807702 @default.
• W2433139937 hasConceptScore W2433139937C126322002 @default.
• W2433139937 hasConceptScore W2433139937C181199279 @default.
• W2433139937 hasConceptScore W2433139937C185592680 @default.
• W2433139937 hasConceptScore W2433139937C2775895851 @default.
• W2433139937 hasConceptScore W2433139937C2776125364 @default.
• W2433139937 hasConceptScore W2433139937C2776382133 @default.
• W2433139937 hasConceptScore W2433139937C2778461978 @default.
• W2433139937 hasConceptScore W2433139937C2778904437 @default.
• W2433139937 hasConceptScore W2433139937C2781099255 @default.
• W2433139937 hasConceptScore W2433139937C2781208047 @default.
• W2433139937 hasConceptScore W2433139937C2909962599 @default.
• W2433139937 hasConceptScore W2433139937C515207424 @default.
• W2433139937 hasConceptScore W2433139937C55493867 @default.
• W2433139937 hasConceptScore W2433139937C71924100 @default.
• W2433139937 hasConceptScore W2433139937C86807702 @default.
• W2433139937 hasFunder F4320334779 @default.
• W2433139937 hasIssue "22" @default.
• W2433139937 hasLocation W24331399371 @default.
• W2433139937 hasLocation W24331399372 @default.
• W2433139937 hasLocation W24331399373 @default.
• W2433139937 hasOpenAccess W2433139937 @default.
• W2433139937 hasPrimaryLocation W24331399371 @default.
• W2433139937 hasRelatedWork W1560801995 @default.
• W2433139937 hasRelatedWork W1575331323 @default.
• W2433139937 hasRelatedWork W183374419 @default.
• W2433139937 hasRelatedWork W1970998776 @default.
• W2433139937 hasRelatedWork W1981647584 @default.
• W2433139937 hasRelatedWork W2006372610 @default.
• W2433139937 hasRelatedWork W2045631642 @default.

• next