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- W2433182116 abstract "Natural Igs, mainly IgM, comprise part of the innate immune system present in healthy individuals, including antigen-free mice. These Igs are thought to delay pathogenicity of infecting agents until antigen-induced high affinity Igs of all isotypes are produced. Previous studies suggested that the acquired humoral response arises directly from the innate response, i.e., that B cells expressing natural IgM, upon antigen encounter, differentiate to give rise both to cells that secrete high amounts of IgM and to cells that undergo affinity maturation and isotype switching. However, by using a murine model of influenza virus infection, we demonstrate here that the B cells that produce natural antiviral IgM neither increase their IgM production nor undergo isotype switching to IgG2a in response to the infec- tion. These cells are distinct from the B cells that produce the antiviral response after encounter with the pathogen. Our data therefore demonstrate that the innate and the acquired humoral immunities to influenza virus are separate effector arms of the immune system and that antigen exposure per se" @default.
- W2433182116 created "2016-06-24" @default.
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- W2433182116 date "2016-01-01" @default.
- W2433182116 modified "2023-09-27" @default.
- W2433182116 title "Innate and acquired humoral imn mediated by distinct arms of the" @default.
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- W2433182116 hasPublicationYear "2016" @default.
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