Matches in SemOpenAlex for { <https://semopenalex.org/work/W2433250457> ?p ?o ?g. }
- W2433250457 endingPage "717" @default.
- W2433250457 startingPage "705" @default.
- W2433250457 abstract "Biomaterial vehicles have the potential to facilitate cell transplantation in the central nervous system (CNS). We have previously shown that highly tunable ionic diblock copolypeptide hydrogels (DCH) can provide sustained release of hydrophilic and hydrophobic molecules in the CNS. Here, we show that recently developed non-ionic and thermoresponsive DCH called DCHT exhibit excellent cytocompatibility. Neural stem cell (NSC) suspensions in DCHT were easily injected as liquids at room temperature. DCHT with a viscosity tuned to prevent cell sedimentation and clumping significantly increased the survival of NSC passed through injection cannulae. At body temperature, DCHT self-assembled into hydrogels with a stiffness tuned to that of CNS tissue. After injection in vivo, DCHT significantly increased by three-fold the survival of NSC grafted into healthy CNS. In injured CNS, NSC injected as suspensions in DCHT distributed well in non-neural lesion cores, integrated with healthy neural cells at lesion perimeters and supported regrowing host nerve fibers. Our findings show that non-ionic DCHT have numerous advantageous properties that make them useful tools for in vivo delivery of cells and molecules in the CNS for experimental investigations and potential therapeutic strategies." @default.
- W2433250457 created "2016-06-24" @default.
- W2433250457 creator A5011858801 @default.
- W2433250457 creator A5016688487 @default.
- W2433250457 creator A5026199302 @default.
- W2433250457 creator A5041132154 @default.
- W2433250457 creator A5058481549 @default.
- W2433250457 creator A5070046055 @default.
- W2433250457 creator A5071854307 @default.
- W2433250457 creator A5075875257 @default.
- W2433250457 creator A5086205161 @default.
- W2433250457 date "2015-07-09" @default.
- W2433250457 modified "2023-10-09" @default.
- W2433250457 title "Thermoresponsive Copolypeptide Hydrogel Vehicles for Central Nervous System Cell Delivery" @default.
- W2433250457 cites W1666752930 @default.
- W2433250457 cites W1829036625 @default.
- W2433250457 cites W1899999601 @default.
- W2433250457 cites W1963586813 @default.
- W2433250457 cites W1972385142 @default.
- W2433250457 cites W1974432822 @default.
- W2433250457 cites W1976594128 @default.
- W2433250457 cites W1982850249 @default.
- W2433250457 cites W1988875977 @default.
- W2433250457 cites W1990277219 @default.
- W2433250457 cites W1990394694 @default.
- W2433250457 cites W1990571647 @default.
- W2433250457 cites W1996795547 @default.
- W2433250457 cites W1998753032 @default.
- W2433250457 cites W2004006890 @default.
- W2433250457 cites W2014070367 @default.
- W2433250457 cites W2017980782 @default.
- W2433250457 cites W2018235103 @default.
- W2433250457 cites W2018681635 @default.
- W2433250457 cites W2019203622 @default.
- W2433250457 cites W2021804758 @default.
- W2433250457 cites W2022386400 @default.
- W2433250457 cites W2025381822 @default.
- W2433250457 cites W2031861741 @default.
- W2433250457 cites W2033605190 @default.
- W2433250457 cites W2040871722 @default.
- W2433250457 cites W2047585900 @default.
- W2433250457 cites W2058137643 @default.
- W2433250457 cites W2059601375 @default.
- W2433250457 cites W2060239018 @default.
- W2433250457 cites W2071693257 @default.
- W2433250457 cites W2072633943 @default.
- W2433250457 cites W2072982940 @default.
- W2433250457 cites W2074661552 @default.
- W2433250457 cites W2075971154 @default.
- W2433250457 cites W2076492394 @default.
- W2433250457 cites W2079356804 @default.
- W2433250457 cites W2082868719 @default.
- W2433250457 cites W2098120755 @default.
- W2433250457 cites W2101667799 @default.
- W2433250457 cites W2104135721 @default.
- W2433250457 cites W2104968232 @default.
- W2433250457 cites W2121860798 @default.
- W2433250457 cites W2135376726 @default.
- W2433250457 cites W2141003407 @default.
- W2433250457 cites W2143372016 @default.
- W2433250457 cites W2172266256 @default.
- W2433250457 cites W2325155086 @default.
- W2433250457 cites W2327191065 @default.
- W2433250457 doi "https://doi.org/10.1021/acsbiomaterials.5b00153" @default.
- W2433250457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4991036" @default.
- W2433250457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27547820" @default.
- W2433250457 hasPublicationYear "2015" @default.
- W2433250457 type Work @default.
- W2433250457 sameAs 2433250457 @default.
- W2433250457 citedByCount "31" @default.
- W2433250457 countsByYear W24332504572016 @default.
- W2433250457 countsByYear W24332504572017 @default.
- W2433250457 countsByYear W24332504572018 @default.
- W2433250457 countsByYear W24332504572019 @default.
- W2433250457 countsByYear W24332504572020 @default.
- W2433250457 countsByYear W24332504572021 @default.
- W2433250457 countsByYear W24332504572022 @default.
- W2433250457 countsByYear W24332504572023 @default.
- W2433250457 crossrefType "journal-article" @default.
- W2433250457 hasAuthorship W2433250457A5011858801 @default.
- W2433250457 hasAuthorship W2433250457A5016688487 @default.
- W2433250457 hasAuthorship W2433250457A5026199302 @default.
- W2433250457 hasAuthorship W2433250457A5041132154 @default.
- W2433250457 hasAuthorship W2433250457A5058481549 @default.
- W2433250457 hasAuthorship W2433250457A5070046055 @default.
- W2433250457 hasAuthorship W2433250457A5071854307 @default.
- W2433250457 hasAuthorship W2433250457A5075875257 @default.
- W2433250457 hasAuthorship W2433250457A5086205161 @default.
- W2433250457 hasBestOaLocation W24332504572 @default.
- W2433250457 hasConcept C108586683 @default.
- W2433250457 hasConcept C12554922 @default.
- W2433250457 hasConcept C136229726 @default.
- W2433250457 hasConcept C136834591 @default.
- W2433250457 hasConcept C141071460 @default.
- W2433250457 hasConcept C150903083 @default.
- W2433250457 hasConcept C169760540 @default.
- W2433250457 hasConcept C171250308 @default.
- W2433250457 hasConcept C188027245 @default.