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• W2433336788 startingPage "939" @default.
• W2433336788 abstract "Summary Coumarins, identified as plant secondary metabolites possess diverse biological activities including anti‐angiogenic properties. Daphnetin ( DAP ), a plant derived dihydroxylated derivative of coumarin has shown significant pharmacological properties such as anticancer, anti‐arthritic and anti‐inflammatory. The present study was performed to investigate the anti‐angiogenic potential of DAP , focusing on the mechanism of action. The in vivo anti‐angiogenic potential of DAP was evaluated by vascular endothelial growth factor ( VEGF )‐induced rat aortic ring ( RAR ) assay and chick chorioallantoic membrane ( CAM ) assay. For in vitro evaluation, wounding migration, transwell invasion, tube formation and apoptosis assays were performed on VEGF (8 ng/ mL )‐induced human umbilical vein endothelial cells ( HUVEC s). The cellular mechanism of DAP was examined on TNF α (10 ng/mL) and VEGF ‐induced HUVEC s by extracting the mRNA and protein levels using RT ‐ qPCR and western blotting. Our data demonstrated that DAP inhibited the in vivo angiogenesis in the RAR and CAM assay. DAP also inhibited the different steps of angiogenesis, such as migration, invasion, and tube formation in HUVEC s. DAP inhibited nuclear factor‐κB signalling together including TNF ‐α induced IκBα degradation; phosphorylation of IκB kinase ( IKK α/β) and translocation of the NF ‐κB‐p65 protein. Furthermore, western blotting revealed that DAP significantly down‐regulated the VEGF ‐induced signalling such as c‐Src, FAK , ERK 1/2 and the related phosphorylation of protein kinase B (Akt) and VEGFR 2 expressions. DAP reduced the elevated mRNA expression of iNOS , MMP 2 and also, induced apoptosis in VEGF ‐stimulated HUVEC s by the caspase‐3 dependent pathway. Taken together, this study reveals that DAP may have novel prospective as a new multi‐targeted medication for the anti‐angiogenesis and cancer therapy." @default.
• W2433336788 created "2016-06-24" @default.
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• W2433336788 date "2016-09-01" @default.
• W2433336788 modified "2023-10-07" @default.
• W2433336788 title "Daphnetin inhibits <scp>TNF</scp>‐α and <scp>VEGF</scp>‐induced angiogenesis through inhibition of the <scp>IKK</scp>s/IκBα/<scp>NF</scp>‐κB, Src/<scp>FAK</scp>/<scp>ERK</scp>1/2 and Akt signalling pathways" @default.
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• W2433336788 doi "https://doi.org/10.1111/1440-1681.12608" @default.
• W2433336788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27297262" @default.
• W2433336788 hasPublicationYear "2016" @default.
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