Matches in SemOpenAlex for { <https://semopenalex.org/work/W2433376106> ?p ?o ?g. }
- W2433376106 endingPage "1016" @default.
- W2433376106 startingPage "1006" @default.
- W2433376106 abstract "Non-alcoholic fatty liver disease (NAFLD) represents one of the most common causes of chronic liver disease, and its prevalence is rising worldwide. The occurrence of non-alcoholic steatohepatitis (NASH) is associated with a substantial increase in disease related morbidity and mortality. Accordingly, there has been a surge of innovation surrounding drug development in an effort to off-set the natural progression and long-term risks of this disease. Disease assessment within clinical trials and clinical practice for NAFLD is currently done with liver biopsies. Liver biopsy-based assessments, however, remain imprecise and are not without cost or risk. This carries significant implications for the feasibility and costs of bringing therapeutic interventions to market. A need therefore arises for reliable and highly accurate surrogate end-points that can be used in phase 2 and 3 clinical trials to reduce trial size requirements and costs, while improving feasibility and ease of implementation in clinical practice. Significant advances have now been made in magnetic resonance technology, and magnetic resonance imaging (MRI) and elastrography (MRE) have been demonstrated to be highly accurate diagnostic tools for the detection of hepatic steatosis and fibrosis. In this review article, we will summarize the currently available evidence regarding the use of MRI and MRE among NAFLD patients, and the evolving role these surrogate biomarkers will play in the rapidly advancing arena of clinical trials in NASH and hepatic fibrosis. Furthermore, we will highlight how these tools can be readily applied to routine clinical practice, where the growing burden of NAFLD will need to be met with enhanced monitoring algorithms." @default.
- W2433376106 created "2016-06-24" @default.
- W2433376106 creator A5025171267 @default.
- W2433376106 creator A5025819859 @default.
- W2433376106 creator A5085487679 @default.
- W2433376106 date "2016-11-01" @default.
- W2433376106 modified "2023-10-17" @default.
- W2433376106 title "MRI and MRE for non-invasive quantitative assessment of hepatic steatosis and fibrosis in NAFLD and NASH: Clinical trials to clinical practice" @default.
- W2433376106 cites W1512816181 @default.
- W2433376106 cites W1574141134 @default.
- W2433376106 cites W1583960324 @default.
- W2433376106 cites W1583994372 @default.
- W2433376106 cites W1622799587 @default.
- W2433376106 cites W1811353850 @default.
- W2433376106 cites W1814376565 @default.
- W2433376106 cites W1856151485 @default.
- W2433376106 cites W1917816261 @default.
- W2433376106 cites W1926691574 @default.
- W2433376106 cites W1963682935 @default.
- W2433376106 cites W1965208459 @default.
- W2433376106 cites W1967790911 @default.
- W2433376106 cites W1969201499 @default.
- W2433376106 cites W1969486929 @default.
- W2433376106 cites W1976422995 @default.
- W2433376106 cites W1977036235 @default.
- W2433376106 cites W1980040060 @default.
- W2433376106 cites W1982347274 @default.
- W2433376106 cites W1982702940 @default.
- W2433376106 cites W1983417944 @default.
- W2433376106 cites W1983496515 @default.
- W2433376106 cites W1985442918 @default.
- W2433376106 cites W1990726393 @default.
- W2433376106 cites W1994797654 @default.
- W2433376106 cites W1995194618 @default.
- W2433376106 cites W1995910233 @default.
- W2433376106 cites W2001837599 @default.
- W2433376106 cites W2001958361 @default.
- W2433376106 cites W2002163127 @default.
- W2433376106 cites W2002349285 @default.
- W2433376106 cites W2006766845 @default.
- W2433376106 cites W2008887569 @default.
- W2433376106 cites W2010450923 @default.
- W2433376106 cites W2020372140 @default.
- W2433376106 cites W2021757019 @default.
- W2433376106 cites W2022296797 @default.
- W2433376106 cites W2023393042 @default.
- W2433376106 cites W2032004838 @default.
- W2433376106 cites W2036127581 @default.
- W2433376106 cites W2036817457 @default.
- W2433376106 cites W2039933259 @default.
- W2433376106 cites W2040683617 @default.
- W2433376106 cites W2042640403 @default.
- W2433376106 cites W2043610882 @default.
- W2433376106 cites W2046763434 @default.
- W2433376106 cites W2052276476 @default.
- W2433376106 cites W2053979905 @default.
- W2433376106 cites W2055271056 @default.
- W2433376106 cites W2056220592 @default.
- W2433376106 cites W2056488785 @default.
- W2433376106 cites W2059251195 @default.
- W2433376106 cites W2061405430 @default.
- W2433376106 cites W2062618014 @default.
- W2433376106 cites W2064245412 @default.
- W2433376106 cites W2065788317 @default.
- W2433376106 cites W2066473433 @default.
- W2433376106 cites W2067740038 @default.
- W2433376106 cites W2074874601 @default.
- W2433376106 cites W2076355272 @default.
- W2433376106 cites W2076450230 @default.
- W2433376106 cites W2080675410 @default.
- W2433376106 cites W2082367709 @default.
- W2433376106 cites W2083294154 @default.
- W2433376106 cites W2085666397 @default.
- W2433376106 cites W2085766690 @default.
- W2433376106 cites W2086719465 @default.
- W2433376106 cites W2088301140 @default.
- W2433376106 cites W2088764776 @default.
- W2433376106 cites W2091905345 @default.
- W2433376106 cites W2099184552 @default.
- W2433376106 cites W2099659089 @default.
- W2433376106 cites W2106061083 @default.
- W2433376106 cites W2106871563 @default.
- W2433376106 cites W2106937897 @default.
- W2433376106 cites W2107649622 @default.
- W2433376106 cites W2109250996 @default.
- W2433376106 cites W2109905025 @default.
- W2433376106 cites W2116332678 @default.
- W2433376106 cites W2117827638 @default.
- W2433376106 cites W2117847311 @default.
- W2433376106 cites W2118144789 @default.
- W2433376106 cites W2118812883 @default.
- W2433376106 cites W2119553987 @default.
- W2433376106 cites W2120368275 @default.
- W2433376106 cites W2120600590 @default.
- W2433376106 cites W2121803690 @default.
- W2433376106 cites W2123205520 @default.
- W2433376106 cites W2123549954 @default.
- W2433376106 cites W2125008314 @default.