FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2433451441> ?p ?o ?g. }

• W2433451441 endingPage "80" @default.
• W2433451441 startingPage "275" @default.
• W2433451441 abstract "A common side effect of radiotherapy is the development of fibrosis in the irradiated tissue. To study the effects of methylprednisolone on acute radiation-induced lung injury, we counted neutrophils, lymphocytes, and macrophages, and measured the expression on alveolar macrophages of lymphocyte function associated molecule-1 (LFA-1) in bronchoalveolar lavage fluid recovered from irradiated rat lungs. Twenty 10-week-old male Wistar rats were divided into 4 groups of 5 rats each: (1) a radiation group (R), which received 20 Gy of radiation from 60Co to the left hemithorax in one fraction; (/) a methylprednisolone treatment group (RS), which received the same dose of radiation as the R group, along with 2.0 mg x kg-1 of methylprednisolone (6 alpha methylprednisolone 21-acetate) by intramuscular injection 6 hours before and every 48 hours after irradiation; (3) an untreated control group (C); and (4) a methylprednisolone control group (S), which received the same dosage of methylprednisolone as the RS group. Rats were kept under specific-pathogen-free conditions. Bronchoalveolar lavage of the left lung was done in all 4 groups 2 week after irradiation. The number of neutrophils in the recovered fluid was significantly higher in the R and RS groups than in the C and S groups. The expression of LFA-1 on alveolar macrophages was significantly higher in the R group than in the RS, C, and S groups. The number of neutrophils in bronchoalveolar lavage fluid and the expression of LFA-1 on alveolar macrophages were significantly higher in the R group than in the RS groups. These results suggest that the increase in the expression of LFA-1 on alveolar macrophages and the increase in the number of neutrophils in bronchoalveolar lavage fluid are related to acute radiation-induced lung injury. Methylprednisolone suppressed the expression of LFA-1 on alveolar macrophages and the increase in the number of neutrophils measured in bronchoalveolar lavage fluid 2 weeks after irradiation." @default.
• W2433451441 created "2016-06-24" @default.
• W2433451441 creator A5004135570 @default.
• W2433451441 creator A5005807105 @default.
• W2433451441 creator A5037713392 @default.
• W2433451441 creator A5055375063 @default.
• W2433451441 creator A5058700057 @default.
• W2433451441 date "1996-03-01" @default.
• W2433451441 modified "2023-09-23" @default.
• W2433451441 title "[Suppression by methylprednisolone of the expression of LFA-1 by alveolar macrophages in irradiated rat lungs]." @default.
• W2433451441 cites W1970815880 @default.
• W2433451441 cites W1980209151 @default.
• W2433451441 cites W1982789959 @default.
• W2433451441 cites W1987444332 @default.
• W2433451441 cites W1988569890 @default.
• W2433451441 cites W1995487726 @default.
• W2433451441 cites W2029842056 @default.
• W2433451441 cites W2030033188 @default.
• W2433451441 cites W2051357449 @default.
• W2433451441 cites W2074618658 @default.
• W2433451441 cites W2090840802 @default.
• W2433451441 cites W2135785112 @default.
• W2433451441 cites W2316942600 @default.
• W2433451441 cites W2328284272 @default.
• W2433451441 cites W2088805011 @default.
• W2433451441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8778466" @default.
• W2433451441 hasPublicationYear "1996" @default.
• W2433451441 type Work @default.
• W2433451441 sameAs 2433451441 @default.
• W2433451441 citedByCount "0" @default.
• W2433451441 crossrefType "journal-article" @default.
• W2433451441 hasAuthorship W2433451441A5004135570 @default.
• W2433451441 hasAuthorship W2433451441A5005807105 @default.
• W2433451441 hasAuthorship W2433451441A5037713392 @default.
• W2433451441 hasAuthorship W2433451441A5055375063 @default.
• W2433451441 hasAuthorship W2433451441A5058700057 @default.
• W2433451441 hasConcept C126322002 @default.
• W2433451441 hasConcept C142724271 @default.
• W2433451441 hasConcept C202751555 @default.
• W2433451441 hasConcept C2776804153 @default.
• W2433451441 hasConcept C2777714996 @default.
• W2433451441 hasConcept C2777761686 @default.
• W2433451441 hasConcept C2777961210 @default.
• W2433451441 hasConcept C2778012055 @default.
• W2433451441 hasConcept C2779244956 @default.
• W2433451441 hasConcept C2780372218 @default.
• W2433451441 hasConcept C2781244666 @default.
• W2433451441 hasConcept C55493867 @default.
• W2433451441 hasConcept C71924100 @default.
• W2433451441 hasConcept C86803240 @default.
• W2433451441 hasConceptScore W2433451441C126322002 @default.
• W2433451441 hasConceptScore W2433451441C142724271 @default.
• W2433451441 hasConceptScore W2433451441C202751555 @default.
• W2433451441 hasConceptScore W2433451441C2776804153 @default.
• W2433451441 hasConceptScore W2433451441C2777714996 @default.
• W2433451441 hasConceptScore W2433451441C2777761686 @default.
• W2433451441 hasConceptScore W2433451441C2777961210 @default.
• W2433451441 hasConceptScore W2433451441C2778012055 @default.
• W2433451441 hasConceptScore W2433451441C2779244956 @default.
• W2433451441 hasConceptScore W2433451441C2780372218 @default.
• W2433451441 hasConceptScore W2433451441C2781244666 @default.
• W2433451441 hasConceptScore W2433451441C55493867 @default.
• W2433451441 hasConceptScore W2433451441C71924100 @default.
• W2433451441 hasConceptScore W2433451441C86803240 @default.
• W2433451441 hasIssue "3" @default.
• W2433451441 hasLocation W24334514411 @default.
• W2433451441 hasOpenAccess W2433451441 @default.
• W2433451441 hasPrimaryLocation W24334514411 @default.
• W2433451441 hasRelatedWork W1902906520 @default.
• W2433451441 hasRelatedWork W1965647068 @default.
• W2433451441 hasRelatedWork W1984265631 @default.
• W2433451441 hasRelatedWork W1984640795 @default.
• W2433451441 hasRelatedWork W2047365634 @default.
• W2433451441 hasRelatedWork W2053815514 @default.
• W2433451441 hasRelatedWork W2365921299 @default.
• W2433451441 hasRelatedWork W2433451441 @default.
• W2433451441 hasRelatedWork W2435014391 @default.
• W2433451441 hasRelatedWork W57738156 @default.
• W2433451441 hasVolume "34" @default.
• W2433451441 isParatext "false" @default.
• W2433451441 isRetracted "false" @default.
• W2433451441 magId "2433451441" @default.
• W2433451441 workType "article" @default.