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- W2433474377 abstract "Infectious necrotic hepatitis was experimentally induced in guinea-pigs, rabbits, and—for the first time—in sheep, by the administration of spores of Clostridium novyi (oedematiens) type B to animals which had been infected with metacercariae of Fasciola hepatica 2 weeks previously. In guinea-pigs the disease occurred following intraperitoneal, or oral administration of the spores, but intramuscular or subcutaneous administration of the spores were ineffective. In rabbits the disease occurred following intravenous or oral administration of the spores, but subcutaneous or iutraperitoneal administration were ineffective. Of 6 sheep infected orally with spores after previous infection with varying doses of metacercariae, 4 died of infectious necrotic hepatitis. There was some evidence to suggest that the disease tended to occur in those sheep in which the parenchymal liver damage caused by the flukes was most severe." @default.
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- W2433474377 date "1973-07-01" @default.
- W2433474377 modified "2023-10-16" @default.
- W2433474377 title "Experimental Studies on Infectious Necrotic Hepatitis (Black Disease) of Sheep" @default.
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- W2433474377 doi "https://doi.org/10.1016/s0034-5288(18)33852-9" @default.
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