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- W2433487677 abstract "ver the last years, a number of potent possibilities. Eitl drugs have been developed that instrains evolve duri] hibit HIV-1 replication in vivo. Treatment resistant strains exi regimes involving a combination of three lation before the or or more different drugs can induce a are maintained by decline in virus load by several orders of balance and are se magnitude, as well as a significant rise in the drugs are appli the CD4 cell count. The drugs currently in strains evolve durii use mainly fall into two classes: reverse dosage of treatmen transcriptase inhibitors prevent infection so that the residuw of new cells, whereas protease inhibitors sensitive virus duri] interfere with the production of new inmized. On the oth fectious virions by infected cells. Recent strains exist before pharmaceutical research has focused on the drug on wildthe development of another class of drugs, matter in the long rt the integrase inhibitors, preventing HIV lead to a fast declii from integrating into the genome of its and a fast rise of host cells. Although research is finding weak drug will leac more drugs to combat HIV infection, the wild-type virus and virus is continuously catching up by evolvtant mutants. The ing resistance against these drugs (1-5). remains constant (1 Although combination therapy can result that are resistant to in sustained suppression of virus load in drugs, the strategy s many patients, it is not effective in all more drugs with patients and fails after the emergence of profiles to minimi multidrug-resistant strains (6). Hence, alany virus strain wi though finding new drugs to fight HIV is drugs (14). important for improving our chances for Although it has success, it is equally important to devise distinguish betweel therapy regimes that minimize the chance nisms experiment of drug resistance emerging. To do this, models suggest that we need more detailed information about treatment failure is" @default.
- W2433487677 created "2016-06-24" @default.
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- W2433487677 date "2016-01-01" @default.
- W2433487677 modified "2023-09-27" @default.
- W2433487677 title "HIV therapy: Managing resi" @default.
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