Matches in SemOpenAlex for { <https://semopenalex.org/work/W2433487923> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2433487923 endingPage "6" @default.
- W2433487923 startingPage "61" @default.
- W2433487923 abstract "Some patients with progressive malignant disease have an increase in basal metabolic expenditure as well as total caloric expenditure, but the findings are neither striking nor consistent. Studies of specific metabolic changes in such patients have shown the following. (a) The predominant substrate for energy in these subjects is fatty acid, as in normal humans. Comparative studies show, however, that greater proportions of the oxidative metabolism in patients with cancer are from fatty acids, particularly when exogenous glucose is available. While the free fatty acid levels in plasma decrease appropriately with glucose administration, current evidence suggests that the levels of free fatty acids themselves may not necessarily be directly related to the various disposal mechanisms. (b) Increased glycolysis and gluconeogenesis are present after overnight fasting in the patients with malignant disease, but these processes, which depend on liver metabolism, are appropriately suppressed with exogenous glucose. (c) Evidence is presented that leucine, an amino acid representative of branched-chain amino acids, is not under normal metabolic control in these subjects. For example, semistarvation does not result in diminished levels of branched-chain amino acids as it does in other patients. Also, glucose does not have its ordinary suppressive effect on branched-chain amino acid levels. Leucine turnover is increased in these patients as is the percentage of leucine flux which is oxidized. Limited data support the oxidation of this amino acid. All these data suggest that the peripheral effects of insulin and glucose may not be normally mediated in these subjects. They also suggest that amino acid metabolism and consequently protein metabolism may be unaffected by normal control factors in malignant disease." @default.
- W2433487923 created "2016-06-24" @default.
- W2433487923 creator A5005956503 @default.
- W2433487923 date "1981-01-01" @default.
- W2433487923 modified "2023-09-23" @default.
- W2433487923 title "Oxidation and metabolic interconversion in malignant cachexia." @default.
- W2433487923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7346162" @default.
- W2433487923 hasPublicationYear "1981" @default.
- W2433487923 type Work @default.
- W2433487923 sameAs 2433487923 @default.
- W2433487923 citedByCount "3" @default.
- W2433487923 crossrefType "journal-article" @default.
- W2433487923 hasAuthorship W2433487923A5005956503 @default.
- W2433487923 hasConcept C121608353 @default.
- W2433487923 hasConcept C126322002 @default.
- W2433487923 hasConcept C134018914 @default.
- W2433487923 hasConcept C17093226 @default.
- W2433487923 hasConcept C185592680 @default.
- W2433487923 hasConcept C20251656 @default.
- W2433487923 hasConcept C20904676 @default.
- W2433487923 hasConcept C2776580952 @default.
- W2433487923 hasConcept C2777704314 @default.
- W2433487923 hasConcept C515207424 @default.
- W2433487923 hasConcept C543025807 @default.
- W2433487923 hasConcept C55493867 @default.
- W2433487923 hasConcept C57600042 @default.
- W2433487923 hasConcept C62231903 @default.
- W2433487923 hasConcept C71924100 @default.
- W2433487923 hasConcept C82736064 @default.
- W2433487923 hasConceptScore W2433487923C121608353 @default.
- W2433487923 hasConceptScore W2433487923C126322002 @default.
- W2433487923 hasConceptScore W2433487923C134018914 @default.
- W2433487923 hasConceptScore W2433487923C17093226 @default.
- W2433487923 hasConceptScore W2433487923C185592680 @default.
- W2433487923 hasConceptScore W2433487923C20251656 @default.
- W2433487923 hasConceptScore W2433487923C20904676 @default.
- W2433487923 hasConceptScore W2433487923C2776580952 @default.
- W2433487923 hasConceptScore W2433487923C2777704314 @default.
- W2433487923 hasConceptScore W2433487923C515207424 @default.
- W2433487923 hasConceptScore W2433487923C543025807 @default.
- W2433487923 hasConceptScore W2433487923C55493867 @default.
- W2433487923 hasConceptScore W2433487923C57600042 @default.
- W2433487923 hasConceptScore W2433487923C62231903 @default.
- W2433487923 hasConceptScore W2433487923C71924100 @default.
- W2433487923 hasConceptScore W2433487923C82736064 @default.
- W2433487923 hasLocation W24334879231 @default.
- W2433487923 hasOpenAccess W2433487923 @default.
- W2433487923 hasPrimaryLocation W24334879231 @default.
- W2433487923 hasRelatedWork W1906018046 @default.
- W2433487923 hasRelatedWork W1942855627 @default.
- W2433487923 hasRelatedWork W1999531938 @default.
- W2433487923 hasRelatedWork W2010126391 @default.
- W2433487923 hasRelatedWork W2051058998 @default.
- W2433487923 hasRelatedWork W2152283187 @default.
- W2433487923 hasRelatedWork W2395596137 @default.
- W2433487923 hasRelatedWork W2414365068 @default.
- W2433487923 hasRelatedWork W2433487923 @default.
- W2433487923 hasRelatedWork W4220777773 @default.
- W2433487923 hasVolume "65 Suppl 5" @default.
- W2433487923 isParatext "false" @default.
- W2433487923 isRetracted "false" @default.
- W2433487923 magId "2433487923" @default.
- W2433487923 workType "article" @default.