FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2433588666> ?p ?o ?g. }

• W2433588666 endingPage "213" @default.
• W2433588666 startingPage "206" @default.
• W2433588666 abstract "We have previously reported that oxytocin produces an inward current at a holding potential of -70 mV without a change in glutamatergic excitatory transmission in adult male rat spinal lamina II (substantia gelatinosa; SG) neurons that play a pivotal role in regulating nociceptive transmission. Oxytocin also enhanced GABAergic and glycinergic spontaneous inhibitory transmissions in a manner sensitive to a voltage-gated Na+-channel blocker tetrodotoxin. These actions were mediated by oxytocin-receptor activation. Such a result was different from that obtained by other investigators in young male rat superficial dorsal horn neurons in which an oxytocin-receptor agonist enhanced glutamatergic and GABAergic but not glycinergic spontaneous transmissions. In order to know a developmental change and also sexual difference in the actions of oxytocin, we examined its effect on spontaneous synaptic transmission in adult female and young male rat SG neurons by using the whole-cell patch-clamp technique in spinal cord slices. In adult female rats, oxytocin produced an inward current at -70 mV without a change in excitatory transmission. GABAergic and glycinergic transmissions were enhanced by oxytocin, the duration of which enhancement was much shorter than in adult male rats. In young (11-21 postnatal days) male rats, oxytocin produced not only an inward but also outward current at -70 mV, and presynaptically inhibited or facilitated excitatory transmission, depending on the neurons tested; both GABAergic and glycinergic transmissions were enhanced by oxytocin. The inhibitory transmission enhancements in adult female and young male rats were sensitive to tetrodotoxin. Although the data may not be enough to be estimated, it is suggested that synaptic modulation by oxytocin in SG neurons, i.e., cellular mechanism for its antinociceptive action, exhibits a developmental change and sexual difference." @default.
• W2433588666 created "2016-06-24" @default.
• W2433588666 creator A5022004204 @default.
• W2433588666 creator A5058817968 @default.
• W2433588666 creator A5086950747 @default.
• W2433588666 date "2016-09-01" @default.
• W2433588666 modified "2023-10-17" @default.
• W2433588666 title "Developmental change and sexual difference in synaptic modulation produced by oxytocin in rat substantia gelatinosa neurons" @default.
• W2433588666 cites W1967609781 @default.
• W2433588666 cites W1975008822 @default.
• W2433588666 cites W1992990293 @default.
• W2433588666 cites W1994067213 @default.
• W2433588666 cites W2009031812 @default.
• W2433588666 cites W2010188929 @default.
• W2433588666 cites W2015140100 @default.
• W2433588666 cites W2032591672 @default.
• W2433588666 cites W2038152105 @default.
• W2433588666 cites W2045659750 @default.
• W2433588666 cites W2055927016 @default.
• W2433588666 cites W2057396411 @default.
• W2433588666 cites W2061257354 @default.
• W2433588666 cites W2062847482 @default.
• W2433588666 cites W2067039768 @default.
• W2433588666 cites W2074945206 @default.
• W2433588666 cites W2095211751 @default.
• W2433588666 cites W2102414953 @default.
• W2433588666 cites W2117294206 @default.
• W2433588666 cites W2127944199 @default.
• W2433588666 cites W2130034971 @default.
• W2433588666 cites W2144144293 @default.
• W2433588666 cites W2146655845 @default.
• W2433588666 cites W2168161193 @default.
• W2433588666 cites W2170760423 @default.
• W2433588666 cites W4236841827 @default.
• W2433588666 doi "https://doi.org/10.1016/j.bbrep.2016.06.011" @default.
• W2433588666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5613344" @default.
• W2433588666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28955908" @default.
• W2433588666 hasPublicationYear "2016" @default.
• W2433588666 type Work @default.
• W2433588666 sameAs 2433588666 @default.
• W2433588666 citedByCount "2" @default.
• W2433588666 countsByYear W24335886662019 @default.
• W2433588666 countsByYear W24335886662022 @default.
• W2433588666 crossrefType "journal-article" @default.
• W2433588666 hasAuthorship W2433588666A5022004204 @default.
• W2433588666 hasAuthorship W2433588666A5058817968 @default.
• W2433588666 hasAuthorship W2433588666A5086950747 @default.
• W2433588666 hasBestOaLocation W24335886661 @default.
• W2433588666 hasConcept C112592302 @default.
• W2433588666 hasConcept C126322002 @default.
• W2433588666 hasConcept C134018914 @default.
• W2433588666 hasConcept C15490471 @default.
• W2433588666 hasConcept C169760540 @default.
• W2433588666 hasConcept C170493617 @default.
• W2433588666 hasConcept C17077164 @default.
• W2433588666 hasConcept C181612422 @default.
• W2433588666 hasConcept C185592680 @default.
• W2433588666 hasConcept C200170125 @default.
• W2433588666 hasConcept C2776176026 @default.
• W2433588666 hasConcept C2776741303 @default.
• W2433588666 hasConcept C2777756961 @default.
• W2433588666 hasConcept C2779177108 @default.
• W2433588666 hasConcept C2780648746 @default.
• W2433588666 hasConcept C35599011 @default.
• W2433588666 hasConcept C515207424 @default.
• W2433588666 hasConcept C55493867 @default.
• W2433588666 hasConcept C61174792 @default.
• W2433588666 hasConcept C71924100 @default.
• W2433588666 hasConcept C86803240 @default.
• W2433588666 hasConceptScore W2433588666C112592302 @default.
• W2433588666 hasConceptScore W2433588666C126322002 @default.
• W2433588666 hasConceptScore W2433588666C134018914 @default.
• W2433588666 hasConceptScore W2433588666C15490471 @default.
• W2433588666 hasConceptScore W2433588666C169760540 @default.
• W2433588666 hasConceptScore W2433588666C170493617 @default.
• W2433588666 hasConceptScore W2433588666C17077164 @default.
• W2433588666 hasConceptScore W2433588666C181612422 @default.
• W2433588666 hasConceptScore W2433588666C185592680 @default.
• W2433588666 hasConceptScore W2433588666C200170125 @default.
• W2433588666 hasConceptScore W2433588666C2776176026 @default.
• W2433588666 hasConceptScore W2433588666C2776741303 @default.
• W2433588666 hasConceptScore W2433588666C2777756961 @default.
• W2433588666 hasConceptScore W2433588666C2779177108 @default.
• W2433588666 hasConceptScore W2433588666C2780648746 @default.
• W2433588666 hasConceptScore W2433588666C35599011 @default.
• W2433588666 hasConceptScore W2433588666C515207424 @default.
• W2433588666 hasConceptScore W2433588666C55493867 @default.
• W2433588666 hasConceptScore W2433588666C61174792 @default.
• W2433588666 hasConceptScore W2433588666C71924100 @default.
• W2433588666 hasConceptScore W2433588666C86803240 @default.
• W2433588666 hasFunder F4320320912 @default.
• W2433588666 hasLocation W24335886661 @default.
• W2433588666 hasLocation W24335886662 @default.
• W2433588666 hasLocation W24335886663 @default.
• W2433588666 hasLocation W24335886664 @default.
• W2433588666 hasOpenAccess W2433588666 @default.
• W2433588666 hasPrimaryLocation W24335886661 @default.
• W2433588666 hasRelatedWork W1505214212 @default.

• next