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- W2433843971 abstract "Pharmacokinetics of methotrexate renal elimination was investigated in patients with cancer given a single intravenous injection. Elimination coefficient ke (0.151 + 0.05 h-1) and half-life t0.5 (5.3 +/- 2.9 h) were calculated. A percentage of methotrexate dose eliminated with the urine was determined (26.0-97.1%) in both unchanged and bound forms. It was found that methotrexate is eliminated in the form of glucuronates and sulfates (2-25% of the administered dose). It was also noted, that pH of the urine exerts an effect on the amount of eliminated methotrexate." @default.
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- W2433843971 date "1992-06-15" @default.
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- W2433843971 title "[Pharmacokinetics of urinary excretion of methotrexate (MTX) in patients with malignant tumors]." @default.
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