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• W243428369 abstract "Publisher Summary Substituted heterocyclic compounds offer a high degree of structural diversity and have proven to be broadly useful as therapeutic agents. The derivatization on the solid phase of preassembled heterocyclic core scaffolds is an attractive approach for the high-throughput synthesis of new chemical entities for activity screens. The novel scaffold material may be prepared in bulk, typically in solution. Subsequently, it is loaded onto a solid support that is then appropriately portioned for multiple derivatizations in parallel. The latter may involve common reactions, but the resulting products are novel. Validated protocols of standard reactions applicable to a variety of solid-supported substrates are useful tools that can be used repeatedly as long as the supply of novel scaffolds is maintained. This chapter exemplifies this type of derivatization strategy on a number of cases, with a well-documented experimental protocol. Particular emphasis is put on the nucleophilic aromatic displacements (S N Ar), a type of reaction that is potentially useful on a large variety of appropriate precursors; for example, on halogenated cores." @default.
• W243428369 created "2016-06-24" @default.
• W243428369 creator A5015038759 @default.
• W243428369 creator A5035717171 @default.
• W243428369 creator A5061258831 @default.
• W243428369 date "2003-01-01" @default.
• W243428369 modified "2023-09-23" @default.
• W243428369 title "Derivatization Reactions of Heterocyclic Scaffolds on Solid Phase: Tools for the Synthesis of Drug-Like Molecule Libraries" @default.
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• W243428369 doi "https://doi.org/10.1016/s0076-6879(03)69023-3" @default.
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• W243428369 hasPublicationYear "2003" @default.
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